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Sera from different age cohorts in Belgium show limited cross-neutralization between the mumps vaccine and outbreak strains. Vlaams Instituut voor Biotechnologie KU Leuven
Unravelling the antigenic landscape of the HIV-1 subtype A envelope of an individual with broad cross-neutralizing antibodies using phage display peptide libraries Instituut voor Tropische Geneeskunde
Broad cross-neutralizing antibodies from persons infected with HIV-1 target a variety of epitopes. Identification of these HIV-1 epitopes may result in an optimal panel of antigenic peptides to be included in a prophylactic vaccine. Phage display peptide libraries were used to unravel the antigenic landscape of an individual (ITM1) infected with HIV-1 subtype A with broad cross-neutralizing antibodies. A stringent selection strategy resulted in ...
Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies Instituut voor Tropische Geneeskunde
Inter-subtype cross-neutralizing antibodies recognize epitopes on cell-associated HIV-1 virions Instituut voor Tropische Geneeskunde
Epitopes corresponding to the envelope genetic subtype are present on the surface of free virions of HIV-1 group M primary isolates and can be detected in neutralization assays with extended incubation phases Instituut voor Tropische Geneeskunde
Cross-neutralizing antibodies against primary isolates in African women infected with HIV-1 [letter] Instituut voor Tropische Geneeskunde
Potent broad cross-neutralizing sera inhibit attachment of primary HIV-1 isolates (groups M and O) to peripheral blood mononuclear cells Instituut voor Tropische Geneeskunde
Establishment of novel enterovirus mouse models to assess the efficacy of new antivirals and the potential development of drug resistance. KU Leuven
Within the Enterovirus genus (EV, family Picornaviridae), rhinoviruses (RVs) are grouped in three species: RV-A, RV-B and RV-C. For long, these viruses were considered non-harmful pathogens of the human upper respiratory tract. However, RV infections of the lower respiratory tract are increasingly reported. Moreover, these viruses have been associated with severe exacerbations of asthma and chronic obstructive pulmonary disease (COPD). With more ...
The Lyssavirus glycoprotein: A key to cross-immunity KU Leuven Universiteit Gent
Rabies is an acute viral encephalomyelitis in warm-blooded vertebrates, caused by viruses belonging to Rhabdovirus family and genus Lyssavirus. Although rabies is categorised as a neglected disease, the rabies virus (RABV) is the most studied amongst Lyssaviruses which show nearly identical infection patterns. In efforts to improving post-exposure prophylaxis, several anti-rabies monoclonal antibodies (mAbs) targeting the glycoprotein (G ...