Connexin and pannexin (hemi)channels in the liver Vrije Universiteit Brussel
The liver was among the first organs in which connexin proteins have been identified. Hepatocytes mainly harbour connexin32, while non-parenchymal liver cells typically produce connexin43. Connexins give raise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions. Both hemichannels and gap junctions provide pathways for communication, namely at the extracellular and intercellular level, respectively. Over the ...