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Towards a Real-Life Understanding of the Altered Functional Behaviour of the Default Mode and Salience Network in Chronic Pain: Are People with Chronic Pain Overthinking the Meaning of Their Pain? Vrije Universiteit Brussel KU Leuven

Elin Johansson, Huanyu Xiong, Andrea Polli, Iris Coppieters, Jo Nijs

Chronic pain is a source of substantial physical and psychological suffering, yet a clear understanding of the pathogenesis of chronic pain is lacking. Repeated studies have reported an altered behaviour of the salience network (SN) and default mode network (DMN) in people with chronic pain, and a majority of these studies report an altered behaviour of the dorsal ventromedial prefrontal cortex (vmPFC) within the anterior DMN. In this topical ...

Reduced pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study Vrije Universiteit Brussel

Mira Meeus, Nathalie Roussel, Steven Truijen, Jo Nijs
Objective. We aimed at examining 1) baseline pressure pain thresholds (PPTs) in Chronic Fatigue Syndrome (CFS) and Chronic Low Back Pain (CLBP) patients compared to healthy subjects, 2) the change in mean PPT in response to exercise, and 3) the possible association with exercise-induced increase in nitric oxide (NO).
Design. Experimental case-control study.
Participants. Twenty-six CFS-patients suffering from chronic pain, 21 ...

Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study Universiteit Gent

Mira Meeus, Nathalie A Roussel, Steven Truijen, Jo Nijs
Objective The aims of this study were to examine (i) base line pressure pain thresholds in patients with chronic fatigue syndrome and those with chronic low back pain compared with healthy subjects, (ii) the change in mean pain threshold in response to exercise, and (iii) associations with exercise induced increase in nitric oxide Participants Twenty six patients with chronic fatigue syndrome suffering of chronic pain, 21 patients with chronic ...

Meaningful coping with chronic pain: Exploring the interplay between goal violation, meaningful coping strategies and life satisfaction in chronic pain patients KU Leuven

Jessie Dezutter, Laura Dewitte, Evalyne Thauvoye, Siebrecht Vanhooren
Trying to cope with chronic pain is a highly demanding and challenging task and pain patients often need to reformulate goals or aspirations due to their pain condition. This goal violation is often related with experienced distress and requires coping processes in order to decrease the distress and stimulate a healthy adaptation. Some scholars, however, argued that in so-called unsolvable or irreparable stressors such as chronic pain, ...

Central pain modulation and cognitive functioning in patients with traumatic and non-traumatic chronic neck pain: preliminary results Universiteit Gent

Iris Coppieters, Barbara Cagnie, Lieven Danneels, Kelly Ickmans, Mira Meeus
Background: Scientific research demonstrates the presence of central sensitization (CS) and cognitive deficits in patients with chronic whiplash associated disorders (CWAD). However, the underlying mechanisms are still unclear. To date, research regarding central pain modulation and cognitive performance in chronic non-traumatic neck pain patients is lacking. Aims: To examine central pain modulation and cognitive functioning in patients with ...

Development and feasibility testing of a Pain Neuroscience Education program for children with chronic pain: treatment protocol Vrije Universiteit Brussel KU Leuven Universiteit Antwerpen Universiteit Gent

Roselien Pas, Mira Meeus, Anneleen Malfliet, Isabel Baert, Sophie Van Oosterwijck, Laurence Leysen, Jo Nijs, Kelly Ickmans
BACKGROUND:
Current treatment for adults with chronic pain often includes Pain Neuroscience Education (PNE) to make people understand the nature underlying their pain and thus provides a clear rational for a biopsychosocial approach. Despite recommendations to use Pain Neuroscience Education as well in children with chronic pain, a specific program, tailored to children aged 6-12 years is lacking.

OBJECTIVES:
The aim of this ...

A modern neuroscience approach to chronic spinal pain: combining pain neuroscience education with cognition-targeted motor control training Universiteit Gent Universiteit Antwerpen

Jo Nijs, Mira Meeus, Barbara Cagnie, Nathalie A Roussel, Mieke Dolphens, Jessica Van Oosterwijck, Lieven Danneels
Chronic spinal pain (CSP) is a severely disabling disorder, including nontraumatic chronic low back and neck pain, failed back surgery, and chronic whiplash-associated disorders. Much of the current therapy is focused on input mechanisms (treating peripheral elements such as muscles and joints) and output mechanisms (addressing motor control), while there is less attention to processing (central) mechanisms. In addition to the compelling ...