Publicaties
Evaluation of Sysmex UF-1000i for use in cerebrospinal fluid analysis Universiteit Gent
Volumetric absorptive microsampling as an alternative sampling strategy for the determination of paracetamol in blood and cerebrospinal fluid Universiteit Gent
The influence of cerebrospinal fluid on blood coagulation and the implications for ventriculovenous shunting Universiteit Gent
Transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL-syndrome) with an acute confusional state and papilledema in a 10-year old girl: a case report. Vrije Universiteit Brussel
present a 10-year-old girl, with three episodes of HaNDL-syndrome, each characterized by slightly different neurological symptoms and signs. As HaNDL is a rare
syndrome, a standardized therapeutic strategy has not been established. Treatment mainly consists of supportive ...
Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer's Disease Vrije Universiteit Brussel Universiteit Antwerpen
BACKGROUND: Apolipoprotein E (ApoE) has been extensively studied in Alzheimer's disease (AD), but little is known of apolipoprotein A-I (ApoA-I) in cerebrospinal fluid (CSF).
OBJECTIVE: Plasma lipids as well as ApoA-I and ApoE in plasma and CSF were determined and related to Mini-Mental State Examination (MMSE) score, APOE genotype, and CSF AD biomarkers.
METHODS: Consecutive patients with AD (n = 29), stable mild cognitive ...
7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier Vrije Universiteit Brussel Universiteit Antwerpen
There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We confirm a recent report describing the presence of this metabolite in cerebrospinal fluid (CSF) at a relatively high concentration. A simple and accurate method was developed for assay of 7-HOCA in ...
Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study Vrije Universiteit Brussel Universiteit Antwerpen
MicroRNAs (miRNAs) regulate translational inhibition of proteins, but are also detected in body fluids, including cerebrospinal fluid (CSF), where they may serve as disease-specific biomarkers. Previously, we showed differential expression of miR-146a, miR-29a, and miR-125b in the CSF of Alzheimer's disease (AD) patients versus controls. In this study, we aim to confirm these findings by using larger, independent sample cohorts of AD patients ...
Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects Vrije Universiteit Brussel Universiteit Antwerpen
In a large multicentre sample of cognitively normal subjects, as a function of age, gender and APOE genotype, we studied the frequency of abnormal cerebrospinal fluid levels of Alzheimer's disease biomarkers including: total tau, phosphorylated tau and amyloid-β1-42. Fifteen cohorts from 12 different centres with either enzyme-linked immunosorbent assays or Luminex® measurements were selected for this study. Each centre sent nine new ...
Selecting Aβ isoforms for an Alzheimer's disease cerebrospinal fluid biomarker panel Vrije Universiteit Brussel Universiteit Antwerpen
Although the core cerebrospinal fluid Alzheimer's disease (AD) biomarkers amyloid-β (Aβ1-42) and tau show a high diagnostic accuracy, there are still limitations due to overlap in the biomarker levels with other neurodegenerative and dementia disorders. During Aβ1-42 production and clearance in the brain, several other Aβ peptides and amyloid precursor protein fragments are formed that could potentially serve as biomarkers for this ongoing ...