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Idiopathic tumoral calcinosis Universiteit Antwerpen Universiteit Gent

Teaching Point: The imaging clues to differentiate idiopathic tumoral calcinosis from other calcified soft tissue lesions include: pseudotumoral appearance with mass effect, bone erosion with intra-osseous protrusion of calcification, lobulated morphology, and peri-articular location on the extensor side.

From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders Universiteit Gent

Eva De Vilder, Olivier Vanakker
Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality. Further, pathologic mineralization is seen in several rare genetic disorders, which often present life-threatening phenotypes. These disorders are classified based on the mechanisms through which the mineralization occurs: ...

Focus on echovascular imaging assessment of arterial disease Vrije Universiteit Brussel

Muriel Sprynger, Fausto Rigo, Marie Moonen, Monica L de Alcantara, Katerina K Naka, Serge Kownator, Iana Simova

The main goal of the present document is to provide a set of practical recommendations for ultrasound imagers who are interested in artery diseases or for physicians who intend to undertake vascular procedures. This is the first part of the work. It is dedicated to general principles of ultrasonography, cervicoencephalic, subclavian, aortoiliac and lower extremity arteries, abdominal aorta, and popliteal aneurysms. It also discusses ...

Comparison of the Quantity of Calcium in the Aortic Valve and the Coronary Arteries in Men Versus Women Who Underwent Transcatheter Aortic Valve Implantation Universiteit Hasselt

Gurpreet K. Singh, E. Mara Vollema, Jan STASSEN, Alexander van Rosendael, Tea Gegenava, Frank van der Kley, Juhani Knuuti, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax, et al.
Several studies have shown an association between aortic stenosis (AS) and coronary atherosclerosis. This study aimed to evaluate the gender differences in aortic valve calcium (AVC) and coronary artery calcium (CAC) and the association between CAC and allcause mortality in patients with severe AS. A total of 260 patients (80 7 years, 39% men) with severe AS who were scheduled for transcatheter aortic valve implantation (TAVI) were included. AVC ...

Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats Vrije Universiteit Brussel

Bram Roosens, Gezim Bala, Kris Gillis, Isabel Remory, Steven Droogmans, Joan Somja, Eléonore Delvenne, Joeri De Nayer, Johan Schiettecatte, Philippe Delvenne, et al.

BACKGROUND: Calcification is an independent predictor of mortality in calcific aortic valve disease (CAVD). The aim of this study was to evaluate the use of non-invasive, non-ionizing echocardiographic calibrated integrated backscatter (cIB) for monitoring progression and subsequent regression of aortic valvular calcifications in a rat model of reversible renal failure with CAVD, compared to histology.

METHODS: 28 male Wistar rats ...

Osteosarcoma with extensive calcified pleural metastases at diagnosis Vrije Universiteit Brussel Universiteit Gent

N. Verbeke, K Verstraete, G Sys, Ramses Forsyth, D Kluyskens, H. Denys, Dirk Uyttendaele, S Rottey

We report the case of an 18 year old woman presenting with shortness of breath and pain in the left shoulder. Imaging of the lungs revealed pleural effusion and calcification of the left pleura. An osteosarcoma of the left humerus was the final diagnosis. A review of the literature reveals that calcified pleural metastatic disease in cases of osteosarcoma has been infrequently reported. Other causes of pleural calcification are briefly ...

Skin manifestations in CDG KU Leuven

Daisy Rymen
The group of congenital disorders of glycosylation (CDG) has expanded tremendously since its first description in 1980, with around 70 distinct disorders described to date. A great phenotypic variability exists, ranging from multisystem disease to single organ involvement. Skin manifestations, although inconsistently present, are part of this broad clinical spectrum. Indeed, the presence of inverted nipples, fat pads and orange peel skin in a ...

Hand Radiological Damage in Systemic Sclerosis: Comparison with a Control Group and Clinical and Functional Correlations KU Leuven Universiteit Gent

Ellen De Langhe, Rene Westhovens
OBJECTIVE:: To define the burden of hand radiological damage in systemic sclerosis (SSc) patients, compared with a control group. METHODS:: Both hands of 167 SSc patients and 168 hands (82 right and 86 left) of age- and gender-matched controls were imaged by conventional radiograph. Two musculoskeletal radiologists semiquantitatively scored the following lesions: tuft acro-osteolysis, tuft calcinosis, joint space narrowings, marginal erosions, ...

The clinical phenotype of systemic sclerosis patients with anti-PM/Scl antibodies : results from the EUSTAR cohort Universiteit Gent KU Leuven

Maria-Grazia Lazzaroni, Emiliano Marasco, Corrado Campochiaro, Jeska DeVries-Bouwstra, Montserrat-Ixchel Gonzalez-Perez, Jorge Rojas-Serrano, Eric Hachulla, Elisabetta Zanatta, Simone Barsotti, Federica Furini, et al.
Objective. To evaluate clinical associations of anti-PM/Scl antibodies in patients with SSc in a multicentre international cohort, with particular focus on unresolved issues, including scleroderma renal crisis (RC), malignancies, and functional outcome of interstitial lung disease (ILD). Methods. (1) Analysis of SSc patients from the EUSTAR database: 144 anti-PM/Scl+ without SSc-specific autoantibodies were compared with 7202 anti-PM/Scl-, and ...