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Associations of Urinary Caffeine and Caffeine Metabolites With Arterial Stiffness in a Large Population-Based Study KU Leuven

Jan A Staessen
OBJECTIVE: To assess the influence of caffeine on arterial stiffness by exploring the association of urinary excretion of caffeine and its related metabolites with pulse pressure (PP) and pulse wave velocity (PWV). PARTICIPANTS AND METHODS: Families were randomly selected from the general population of 3 Swiss cities from November 25, 2009, through April 4, 2013. Pulse pressure was defined as the difference between the systolic and diastolic ...

Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions KU Leuven

Jan A Staessen, Yumei Gu
Intake of caffeinated beverages might be associated with reduced cardiovascular mortality possibly via the lowering of blood pressure. We estimated the association of ambulatory blood pressure with urinary caffeine and caffeine metabolites in a population-based sample. Families were randomly selected from the general population of Swiss cities. Ambulatory blood pressure monitoring was conducted using validated devices. Urinary caffeine, ...

Estimation of caffeine intake from analysis of caffeine metabolites in wastewater Universiteit Antwerpen

Emma Gracia-Lor, Nikolaos I. Rousis, Ettore Zuccato, Richard Bade, Jose Antonio Baz-Lomba, Erika Castrignano, Ana Causanilles, Felix Hernandez, Barbara Kasprzyk-Hordern, Juliet Kinyua, et al.
Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable ...

Genotyping-by-sequencing provides the first well-resolved phylogeny for coffee (Coffea) and insights into the evolution of caffeine content in its species: GBS coffee phylogeny and the evolution of caffeine content. Plantentuin Meise / Agentschap Plantentuin Meise

Perla Hamon, Corrine E. Grover, Aaron P. Davis, Jean-Jacques Rakotomalala, Nathalie E. Raharimalala, Victor A. Albert, Hosahalli L. Sreenath, Piet Stoffelen, Sharon E. Mitchell, Emmanuel Couturon, et al.
A comprehensive and meaningful phylogenetic hypothesis for the commercially important coffee genus (Coffea) has long been a key objective for coffee researchers. For molecular studies, progress has been limited by low levels of sequence divergence, leading to insufficient topological resolution and statistical support in phylogenetic trees, particularly for the major lineages and for the numerous species occurring in Madagascar. We report here ...

Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions (vol 65, pg 691, 2015) KU Leuven

I Guessous, M Pruijm, B Ponte, D Ackermann, G Ehret, N Ansermot, P Vuistiner, Jan A Staessen, Yumei Gu, F Paccaud, et al.
In the article by Guessous et al (Guessous I, Pruijm M, Ponte B, Ackermann D, Ehret G, Ansermot N, Vuistiner P, Staessen J, Gu Y, Paccaud F, Mohaupt M, Vogt B, Pechère-Bertschi A, Martin PY, Burnier M, Eap CB, Bochud M. Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions. Hypertension. 2015;65:691–696. doi: 10.1161/HYPERTENSIONAHA.114.04512), which published online ahead of print December 8, 2014, ...

Effect of caffeine on sleep and behaviour in nursing home residents with dementia Vrije Universiteit Brussel

L M M de Pooter-Stijnman, Susan Vrijkotte, Martin Smalbrugge

Background and goal: Sleep problems and challenging behavioural symptoms are frequently reported among nursing home residents with dementia. Coffee with caffeine is consumed frequently by these residents and can have a negative effect on sleep and behaviour in older persons with dementia. In this interventional study, the effect of caffeine reduction on sleep and challenging behavioural symptoms in nursing home residents with dementia was ...

Combined intake of caffeine and low-dose glucose to reduce exercise-related hypoglycaemia in individuals with type 1 diabetes on ultra-long-acting insulin degludec : a randomized, controlled, double-blind, cross-over trial Universiteit Gent

Tobias Kuhne, Esme Wallace, David Herzig, Simon Helleputte, Sam Scott, Jordan Pickles, Andreas Melmer, Christoph Stettler
Aim To evaluate whether caffeine combined with a moderate amount of glucose reduces the risk for exercise-related hypoglycaemia compared with glucose alone or control in adult people with type 1 diabetes using ultra-long-acting insulin degludec. Materials and Methods Sixteen participants conducted three aerobic exercise sessions (maximum 75 min) in a randomized, double-blind, cross-over design. Thirty minutes before exercise, participants ...

Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? : a comparative study Universiteit Gent

Pieter De Kesel, Willy Lambert, Christophe Stove
Volumetric absorptive microsampling (VAMS) is a novel sampling technique that allows the straightforward collection of an accurate volume of blood (approximately 10 mu L) from a drop or pool of blood by dipping an absorbent polymeric tip into it. The resulting blood microsample is dried and analyzed as a whole. The aim of this study was to evaluate the potential of VAMS to overcome the hematocrit bias, an important issue in the analysis of dried ...