Publicaties
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A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation KU Leuven
Estrogen receptor α (ERα) is an enhancer activating transcription factor, a key driver of breast cancer and a main target for cancer therapy. ERα-mediated gene regulation requires proper chromatin-conformation to facilitate interactions between ERα-bound enhancers and their target promoters. A major determinant of chromatin structure is the CCCTC-binding factor (CTCF), that dimerizes and together with cohesin stabilizes chromatin loops and forms ...
CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum KU Leuven
PURPOSE: Pathogenic variants in the chromatin organizer CTCF were previously reported in seven individuals with a neurodevelopmental disorder (NDD). METHODS: Through international collaboration we collected data from 39 subjects with variants in CTCF. We performed transcriptome analysis on RNA from blood samples and utilized Drosophila melanogaster to investigate the impact of Ctcf dosage alteration on nervous system development and function. ...
Global alteration of CTCF binding in the cancer genome Universiteit Gent
TET-catalyzed 5-carboxylcytosine promotes CTCF binding to suboptimal sequences genome-wide Universiteit Gent
Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans Vrije Universiteit Brussel
OBJECTIVE: Connective tissue growth factor (CTGF) is an important regulator of fibrogenesis in many organs. This study evaluated the interrelationship among adipose tissue CTGF expression, fat mass, and insulin resistance in humans.
METHODS: This study examined (1) CTGF gene expression in human subcutaneous preadipocytes before and after inducing adipogenesis; (2) relationships among abdominal subcutaneous adipose tissue CTGF gene ...
MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure KU Leuven
To understand the process of cardiac aging, it is of crucial importance to gain insight into the age-related changes in gene expression in the senescent failing heart. Age-related cardiac remodeling is known to be accompanied by changes in extracellular matrix (ECM) gene and protein levels. Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of ...
Mutated CTSF in adult-onset neuronal ceroid lipofuscinosis and FTD Universiteit Gent Universiteit Antwerpen Vrije Universiteit Brussel
Automated enumeration and phenotypic characterization of CTCs and tdEVs in patients with metastatic castration resistant prostate cancer Universiteit Gent Universiteit Antwerpen
Efficient label-free CTC enrichment using novel elevated height chip chamber by vortex technology Vrije Universiteit Brussel
Circulating tumor cells (CTCs) are essential evidence for monitoring tumor dynamics and efficient cancer therapy. Besides its clinical importance, it is a feasible method for liquid biopsy in oncological studies. Vortex is a label-free technique using inertial microfluidic technology to separate CTCs from blood with high throughput. A possible moderate separation efficiency arises due to the loss of particles from the vortex reservoir during ...