Genome engineering through CRISPR/Cas9 technology in the human germline and pluripotent stem cells. Vrije Universiteit Brussel Universiteit Gent
With the recent development of CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome editing technology, the possibility to genetically manipulate the human germline (gametes and embryos) has become a distinct technical possibility. Although many technical challenges still need to be overcome in order to achieve adequate efficiency and precision of the technology in human embryos, the path leading to ...