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Functional Programming Abstractions for CP Modeling (CP modellering met functionele abstracties) KU Leuven

The field of Constraint Programming (CP) provides problem-independent technology for solving combinatorial problems.The programmer describes his problem in a model, which is processed by a problem-independent solver to produce a solution. Solver implementations arean active topic of research, and many efficient solvers exist. Specific languages werecreated that provide CP modeling facilities, but these domain-specificlanguages (DSL) run behind ...

ANALYSIS OF COQ SYNTHESIS USING LABELED NON RADIOACTIVE SUBSTRATES. APPLICATION FOR THE DIAGNOSIS OF PRIMARY COQ10 DEFICIENCIES. Vrije Universiteit Brussel

N. Bujan, A. Arias, R. Montero, J. Garcia-Villoria, R. Artuch, Paz Briones, A. Ribes
Background: CoQ10 deficiencies are associated to mutations in genes of
CoQ biosynthesis and respond to CoQ10 supplementation. Early treatment
allows better outcome. Therefore, early diagnosis is desirable.
Objectives: Developing a non-radioactive methodology for fibroblast CoQ10
biosynthesis quantification that enables discriminating primary deficiencies.
Methods: Fibroblasts were incubated 72 h with 28 ?M 2 H3-mevalonate or ...

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue Universiteit Gent Vlaams Instituut voor Biotechnologie

Zifu Zhong, Yong Chen, Kim Deswarte, Heleen Lauwers, Emily De Lombaerde, Xiaole Cui, Simon Van Herck, Tingting Ye, Mark Gontsarik, Stefan Lienenklaus, et al.
Pharmacological strategies to activate innate immune cells are of great relevance in the context of vaccine design and anticancer immune therapy, to mount broad immune responses able to clear infection and malignant cells. Synthetic CpG oligodeoxynucleotides (CpG-ODNs) are short single-stranded DNA molecules containing unmethylated CpG dinucleotides and a phosphorothioate backbone. Class B CpG ODNs activate robust innate immune responses through ...

Decoupling multivariate functions using a non-parametric filtered CPD approach Vrije Universiteit Brussel

Jan Decuyper, Koen Tiels, Siep Weiland

Black-box model structures are dominated by large multivariate functions. Usually a generic basis function expansion is used, e.g. a polynomial basis, and the parameters of the function are tuned given the data. This is a pragmatic and often necessary step considering the black-box nature of the problem. However, having identified a suitable function, there is no need to stick to the original basis. So-called decoupling techniques aim at ...

Decoupling P-NARX models using filtered CPD Vrije Universiteit Brussel

Jan Decuyper, David Westwick, Kiana Karami

Nonlinear Auto-Regressive eXogenous input (NARX) models are a popular class of nonlinear dynamical models. Often a polynomial basis expansion is used to describe the internal multivariate nonlinear mapping (P-NARX). Resorting to fixed basis functions is convenient since it results in a closed form solution of the estimation problem. The drawback, however, is that the predefined basis does not necessarily lead to a sparse representation of the ...

Complement component C1q is produced by isolated articular chondrocytes KU Leuven

Silvia Monteagudo, Chahrazad CHERIFI, Rik Lories
OBJECTIVE: Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is incompletely understood. Previous studies have shown that chondrocytes express mRNA encoding complement proteins such as C1q, suggesting local protein production, which ...

An efficient CPI stack counter architecture for superscalar processors Universiteit Gent

Osman Allam, Stijn Eyerman, Lieven Eeckhout
Cycles-Per-Instruction (CPI) stacks provide intuitive and insightful performance information to software developers. Performance bottlenecks are easily identified from CPI stacks, which hint towards software changes for improving performance. Computing CPI stacks on contemporary superscalar processors is non-trivial though because of various overlap effects. Prior work proposed a CPI counter architecture for computing CPI stacks on out-of-order ...

EQUAL CPA Score 2022 : a tool to measure guideline adherence for chronic pulmonary aspergillosis Universiteit Gent

Rosanne Sprute, Eva Van Braeckel, Holger Flick, Martin Hoenigl, Chris Kosmidis, Ritesh Agarwal, Jesper R Davidsen, Christian B Laursen, Oliver A Cornely, Danila Seidel, et al.
Background Chronic pulmonary aspergillosis (CPA) can complicate underlying pulmonary diseases, and clinical management of CPA is challenging. Guidelines support clinicians but due to the complexity of the disease they can be difficult to adhere to. Objectives To map current guideline recommendations for the clinical management of CPA into a scoring tool to facilitate and quantify guideline adherence in clinical practice. Methods Recommendations ...

Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study KU Leuven

Natalie Put, Peter Konings, Yves Moreau, Peter Vandenberghe, Lucienne Michaux
We performed a multicentric study to assess the impact of two different culture procedures on the detection of chromosomal abnormalities in 217 consecutive unselected cases with chronic lymphocytic leukemia (CLL) referred for routine analysis either at the time of diagnosis (n = 172) or during disease evolution (n = 45). Parallel cultures of peripheral blood or bone marrow were set up with the addition of either the conventional B-cell mitogen ...