Publicaties
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Immunopharmacological intervention for successful neural stem cell therapy: New perspectives in CNS neurogenesis and repair. Universiteit Hasselt
The pharmacological support and stimulation of endogenous and transplanted neural stem cells (NSCs) is a major challenge in brain repair. Trauma to the central nervous system (CNS) results in a distinct inflammatory response caused by local and infiltrating immune cells. This makes NSC-supported regeneration difficult due to the presence of inhibitory immune factors which are upregulated around the lesion site. The continual and dual role of the ...
Functional consequences of a close encounter between microglia and brain-infiltrating monocytes during CNS pathology and repair Universiteit Antwerpen
Neuroinflammation is recognized as an important factor contributing to the development and progression of several central nervous system (CNS) disorders. Upon CNS trauma or disease, parenchymal microglia highly proliferate and accumulate in and around the lesion site. In addition, blood-derived monocytes can infiltrate the inflamed CNS in response to cellular damage and/or a compromised blood-brain barrier. Both microglia and infiltrating ...
The role of TNF-α, ADAM17 and IL-13 in CNS injury and repair Universiteit Hasselt
SCI is devastating pathology associated with a significant impact on life expectancy and quality, as well as a considerable economic cost. To date there is no cure available; hence there is an urgent need to identify efficient therapies. In order to achieve this, it is important to clearly identify the temporal and spatial role of specific target molecules; it may well be that some molecules play a regenerative role during the acute phase, while ...
Molecular Basis of Cystinosis: Geographic Distribution, Functional Consequences of Mutations in the CTNS Gene, and Potential for Repair KU Leuven
Mutations in the CTNS gene encoding the lysosomal membrane cystine transporter cystinosin are the cause of cystinosis, an autosomal recessive lysosomal storage disease. More than 140 CTNS mutations have been reported worldwide. Recent studies have discovered that cystinosin exerts other key cellular functions beyond cystine transport such as regulation of oxidative state, lysosomal dynamics and autophagy. Here, we review the different mutations ...
Pros and cons of tacking in laparoscopic hernia repair Universiteit Gent
Fatty Acid Synthesis in Glial Cells of the CNS Universiteit Hasselt
Fatty acids (FAs) are of crucial importance for brain homeostasis and neural function. Glia cells support the high demand of FAs that the central nervous system (CNS) needs for its proper functioning. Additionally, FAs can modulate inflammation and direct CNS repair, thereby contributing to brain pathologies such Alzheimer's disease or multiple sclerosis. Intervention strategies targeting FA synthesis in glia represents a potential therapeutic ...
Fatty acid metabolism in the progression and resolution of CNS disorders Universiteit Hasselt
Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid metabolism and the fatty acid lipidome in health and disease. A growing body of evidence indicates that imbalances in the metabolism and level of fatty acids drive the initiation and progression of central nervous system (CNS) disorders such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. Here, we provide an in-depth overview on the ...
TREM2 in CNS homeostasis and neurodegenerative disease Universiteit Antwerpen
Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and regeneration. The innate immune receptor and its adaptor protein-triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12)-possess the ability to modulate critical cellular functions via crosstalk with diverse signaling ...
Nanomaterial/neuronal hybrid system for functional recovery of the CNS Universiteit Antwerpen
Nanotechnology enters into the realm of basic biological units by its ability to functionally integrate with bio-systems. In recent years we reached an increased interest and improved understanding of such interactions with biological systems at a subcellular level. This latter feature can be understood and engineered with a high degree of specificity. Here, we review current experimental models that promote the development of novel ...