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WHO multicenter evaluation of FACSCount CD4 and Pima CD4 T-cell count systems Instituut voor Tropische Geneeskunde Universiteit Antwerpen
BACKGROUND: CD4⁺ T-cell counts are used to screen and follow-up HIV-infected patients during treatment. As part of the World Health Organization prequalification program of diagnostics, we conducted an independent multicenter evaluation of the FACSCount CD4 and the Pima CD4, using the FACSCalibur as reference method.
METHODS: A total of 440 paired capillary and venous blood samples were collected from HIV-infected patients attending ...
Role of the CD4 count in HIV management Instituut voor Tropische Geneeskunde
Development and evaluation of a clinical algorithm to monitor patients on antiretrovirals in resource-limited settings using adherence, clinical and CD4 cell count criteria Instituut voor Tropische Geneeskunde
The added value of a CD4 count to identify patients eligible for highly active antiretroviral therapy among HIV-positive adults in Cambodia Instituut voor Tropische Geneeskunde
CD4 T-cell count and HIV-1 infection in adults with uncomplicated malaria Instituut voor Tropische Geneeskunde
Validation of primary CD4 gating as an affordable strategy for absolute CD4 counting in Cambodia Instituut voor Tropische Geneeskunde
CD4 results with a bias larger than hundred cells per microliter can have a significant impact on the clinical decision during treatment initiation of HIV patients Instituut voor Tropische Geneeskunde Universiteit Antwerpen
BACKGROUND: CD4 counts are currently used to assess HIV patients for treatment eligibility and to monitor antiretroviral response to treatment. The emerging point-of-care devices could fill an important gap in resource-limited settings. However, the accuracy of CD4-counting instruments is diverse and data on how CD4 measurement errors have an impact on clinical decisions are lacking.
METHODS: Clinicians were queried on the use of CD4 ...
Multisite evaluation of a point-of-care instrument for CD4(+) T-cell enumeration using venous and finger-prick blood: the PIMA CD4 Instituut voor Tropische Geneeskunde
BACKGROUND: CD4(+) T-cell enumeration (CD4 count) is used as a criterion to initiate antiretroviral therapy (ART) in HIV patients and to monitor treatment efficacy. However, simple, affordable, and reliable point-of-care (POC) instruments adapted to resource-limited settings are still lacking. The PIMA CD4 analyzer is a new POC instrument for CD4 counting that uses disposable cartridges and a battery-powered analyzer. METHODS: Whole blood ...
Performance of the PointCare NOW system for CD4 counting in HIV patients based on five independent evaluations Instituut voor Tropische Geneeskunde
INTRODUCTION: Point-of-care (POC) CD4 testing can improve access to treatment by enabling decentralization and reducing patient loss-to-follow-up. As new POC CD4 technologies become available, their performance should be assessed before widespread deployment. This study reports the findings of five independent evaluations of the PointCare NOW CD4 system. MATERIALS/METHODS: Evaluations were conducted in Southern Africa (Mozambique, South Africa) ...