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Microbore LC with UV detection to study the in vivo passage of Compound 21, a non-peptidergic AT2 receptor agonist, to the striatum. Vrije Universiteit Brussel

Naser Shraim, Sophie Sarre
Introduction: Compound 21 (C21) is a non-peptide angiotensin II type 2 (AT2) receptor agonist. It is used to study the role of the AT2 receptor in dopamine release and synthesis in the striatum and to study its possible neuroprotective effects in animal models of Parkinson's disease [1, 2]. In literature, there is no data available on the blood brain barrier (BBB) passage of this compound. In order to investigate its blood brain passage, a ...

36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. KU Leuven

Cornelia Genbrugge, Greet Hermans, Greet Van den Berghe, Lies Langouche, Rose-Lima Van Keer
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis P002 - Lower serum immunoglobulin G2 level does not predispose to severe flu. J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego ...

EEG connectivity between the subgenual anterior cingulate and prefrontal cortices in response to antidepressant medication Vrije Universiteit Brussel Universiteit Gent

Tabitha A Iseger, Mayuresh S Korgaonkar, J Leon Kenemans, Stuart M Grieve, Chris Baeken, Martijn Arns

Antidepressant medication is the most common treatment for major depressive disorder (MDD), however, the precise working mechanism underlying these treatments remains unclear. Recent neuromodulation treatments demonstrate that direct stimulation of the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and subgenual anterior cingulate (sgACC) relate to clinical improvement, suggesting connectivity alterations of ...

Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects Vrije Universiteit Brussel

Tianne Numan, Edwin Van Dellen, Frank P. Vleggaar, Paul van Vlieberghe, Cornelis J Stam, Arjen Slooter

Background. Despite widespread application, little is known about the neurophysiological effects of light sedation with midazolam or propofol, particularly in older subjects. The aim of this study was to assess the effects of light sedation with midazolam or propofol on a variety of EEG measures in older subjects. Methods. In patients (≥60 years without neuropsychiatric disease such as delirium), 2 EEG recordings were performed, before and ...