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Symmetrical Design of Proteins For Modular Building Blocks For Larger Complexes KU Leuven
Proteins can be considered as nature's most diverse building blocks which are involved in the various essential processes that constitute life. However, in the field of synthetic biochemistry and bio-nanotechnology, DNA has been the most successful building block so far to create a variety of shapes and applications, such as diagnosis and drug delivery systems. The preference of DNA over protein building blocks arose due to the fact that the ...
Micro-nanorobots: important considerations when developing novel drug delivery platforms. KU Leuven
Introduction: There is growing emphasis on the development of bioinspired and biohybrid micro/nanorobots for the targeted drug delivery (TDD). Particularly, stimuli-responsive materials and magnetically triggered systems, identified as the most promising materials and design paradigms. Despite the advances made in fabrication and control, there remains a significant gap in clinical translation. Areas covered: This review discusses the ...
Nanomaterial/neuronal hybrid system for functional recovery of the CNS Universiteit Antwerpen
Nanotechnology enters into the realm of basic biological units by its ability to functionally integrate with bio-systems. In recent years we reached an increased interest and improved understanding of such interactions with biological systems at a subcellular level. This latter feature can be understood and engineered with a high degree of specificity. Here, we review current experimental models that promote the development of novel ...
The symmetric designer protein Pizza as a scaffold for metal coordination KU Leuven
Symmetric proteins are currently of interest as they allow creation of larger assemblies and facilitate the incorporation of metal ions in the larger complexes. Recently this was demonstrated by the biomineralization of the cadmium-chloride nanocrystal via the Pizza designer protein. However, the mechanism behind this formation remained unclear. Here, we set out to investigate the mechanism driving the formation of this nanocrystal via ...
Computational design of symmetrical eight-bladed β-propeller proteins KU Leuven
β-Propeller proteins form one of the largest families of protein structures, with a pseudo-symmetrical fold made up of subdomains called blades. They are not only abundant but are also involved in a wide variety of cellular processes, often by acting as a platform for the assembly of protein complexes. WD40 proteins are a subfamily of propeller proteins with no intrinsic enzymatic activity, but their stable, modular architecture and versatile ...
Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies KU Leuven
β-propeller proteins are highly symmetrical, being composed of a repeated motif with four anti-parallel β-sheets arranged around a central axis. Recently we designed the first completely symmetrical β-propeller protein, Pizza6, consisting of six identical tandem repeats. Pizza6 is expected to prove a useful building block for bionanotechnology, and also a tool to investigate the folding and evolution of β-propeller proteins. Folding studies are ...
Use of nano-particles in biosensing KU Leuven
New developments in biofunctionalisation of nanomaterials are a driving force for innovation in bionanotechnology applications. Nanoparticles (NP’s) functionalised with a layer of biomolecules such as proteins and DNA, play a central role in the field of life sciences for their diagnostic and therapeutic properties. They act as miniaturised biosensors or drug delivery vehicles. The properties of the bioconjugated nanomaterials depend both on the ...
Comparison of bacterial cells and amine-functionalized abiotic surfaces as support for Pd nanoparticle synthesis Universiteit Gent
Optimizations, limitations and innovations of biosupported palladium nanocatalysts Universiteit Gent
Palladium (Pd) nanoparticles are more and more applied as catalyst for a wide variety of chemical reactions. Recent research demonstrated that the application in water treatment for the degradation of halogenated contaminants could be feasible. These Pd nanoparticles can be produced in a sustainable way, by precipitating them on the cell wall of bacteria, such as Shewanella oneidensis (U+2018bio-PdU+2019). In order to obtain a catalytic ...