Publicaties
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Associations of four biological age markers with child development: a multi-omic analysis in the European HELIX cohort Universiteit Hasselt
Background: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development remains unclear. We aimed to clarify the relationship of accelerated biological age, assessed through two established biological age indicators, telomere length and DNA methylation age, and two novel candidate biological age ...
Influence of sample collection and preanalytical sample processing on the analyses of biological markers in the European multicentre study IDEFICS Universiteit Gent
Glyphosate and AMPA exposure in relation to markers of biological aging in an adult population-based study Universiteit Antwerpen Universiteit Hasselt KU Leuven Vrije Universiteit Brussel
Background/Aim: Glyphosate, a broad-spectrum herbicide, and its main metabolite aminomethylphosphonic acid (AMPA) are persistent in the environment. Studies showed associations between glyphosate or AMPA exposure and several adverse cellular processes, including metabolic alterations and oxidative stress.& nbsp;Objective: To determine the association between glyphosate and AMPA exposure and biomarkers of biological aging.& nbsp;Methods: ...
Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009 KU Leuven
The article summarizes the expert discussion and recommendations on the use of molecular markers and of biological targeted therapies in metastatic colorectal cancer (mCRC), as well as a proposed treatment decision strategy for mCRC treatment. The meeting was conducted during the 11th ESMO/World Gastrointestinal Cancer Congress (WGICC) in Barcelona in June 2009. The manuscript describes the outcome of an expert discussion leading to an expert ...
Colorectal cancer: biological factors as prognostic markers for a more targeted therapy Universiteit Antwerpen
Traditionally, TNM disease staging has been the main method of determining colorectalcancer (CRC) progress. However, its predictive value is limited since CRC should be regarded as a heterogeneous, multi-pathway disease. Validated prognostic, predictive, and toxicity markers are needed to achieve a more personal intervention, with the potential to increase efficacy and decrease toxicity. Currently, no molecular characteristics have emerged as ...
Biological ageing and frailty markers in breast cancer patients KU Leuven
Older cancer patients are a highly heterogeneous population in terms of global health and physiological reserves, and it is often difficult to determine the best treatment. Moreover, clinical tools currently used to assess global health require dedicated time and lack a standardized end score. Circulating markers of biological age and/or fitness could complement or partially substitute the existing screening tools. In this study we explored the ...
Development and biological evaluation of ⁹⁹mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers KU Leuven
In vivo visualization of tumor hypoxia related markers, such as the endogenous transmembrane protein CA IX may lead to novel therapeutic and diagnostic applications in the management of solid tumors. In this study 4-(2-aminoethyl)benzene sulfonamide (AEBS, K(i) = 33 nM for CA IX) has been conjugated with bis(aminoethanethiol) (BAT) and mercaptoacetyldiglycine (MAG2) tetradendate ligands and the conjugates radiolabelled with (99m)Tc, to obtain ...
Biological markers to differentiate between Alzheimer’s disease and dementia with Lewy bodies Universiteit Antwerpen
abstract not available