Publicaties

Mammalian pre-implantation development is entirely devoted to the specification of extra-embryonic lineages, which are fundamental for embryo morphogenesis and support. The second fate decision is taken just before implantation, as defined by the epiblast (EPI) and the primitive endoderm (PE) specification. Later, EPI forms the embryo proper and PE contributes to the formation of the yolk sac. The formation of EPI and PE as molecularly and ...

This study introduces a SIR (Susceptible-Infectious-Recovered) model using fractional derivatives to assess the population's hesitancy to the COVID-19 vaccination campaign in Portugal. Leveraging the framework developed by Angstmann [1], our approach incorporates fractional derivatives to best describe the nuanced dynamics of the vaccination process. We begin by examining the qualitative properties of the proposed model. To substantiate the ...

Phyllodes tumors (PTs) are rare breast tumors showing overlapping features with fibroadenomas (FAs). Diagnosis on small biopsies is challenging. New diagnostic markers are needed. Here we evaluated immunohistochemical staining of histone 3 trimethyl-lysine-27 (H3K27me3) as a diagnostic and prognostic marker in a series of PTs. Surgically removed PTs at our institution (September 1990 and July 2022) and control FAs. Tissue micro-arrays (4 cores, ...

Objectives: To understand country-level differences in the population's health and well-being in Europe in the aftermath of the COVID-19 pandemic, while also investigating the internal relationships among health and wellbeing outcomes. Study design: Cross-sectional study. Methods: We collected representative panel-based samples of 1000 adult respondents per country across 14 Western European countries in early 2023. The survey used standardised ...

OBJECTIVE: Adhesions between the uterus, bladder and anterior abdominal wall are associated with clinical sequelae, including chronic pelvic pain and dyspareunia, and can also yield complications during surgery. The transvaginal sonographic (TVS) sliding bladder sign is a minimally invasive diagnostic tool to evaluate the presence of vesicouterine adhesions. This study aimed to determine the predictive value and intra- and interobserver ...

Transcutaneous auricular vagus nerve stimulation (taVNS) has been tested as a strategy to facilitate fear extinction learning based on the hypothesis that taVNS increases central noradrenergic activity. Four studies out of six found taVNS to enhance extinction learning especially at the beginning of extinction. Facilitatory effects of taVNS were mainly observed in US expectancy, less in fear-potentiated startle (FPS), and not in the skin ...

‘Populaire politieke liederen’ zijn al dan niet verhalende liederen met een politieke inhoud, die toegankelijk waren voor de non-elite. Deze term vervangt de onduidelijke en anachronistische benaming ‘historieliederen’ uit oudere, letterkundige gevalsstudies. Het bronnencorpus van dit onderzoek behelst alle Middelnederlandse liederen vanaf het oudste overgeleverde Middelnederlandse lied rond 1300 tot de reformatie in 1560. Populaire liederen ...

This study investigates the impact of the overall intensity and changes in grandparental caregiving on loneliness in grandparents in European countries. Data from waves 5 to 8 of the Survey on Health, Ageing, and Retirement in Europe (SHARE) were used (Nindividuals = 30,896 and Nobservations = 48,562). We included grandparents (aged 50 years and over) with at least one grandchild at the beginning of the study. The analyses reveal that any ...