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Effect of need-based care on behavioural and psychological symptoms in residents with dementia and formal caregivers' distress in nursing homes: a three-arm cluster randomized controlled trial Odisee vzw Universiteit Antwerpen

Katrin Gillis
PURPOSE: To evaluate to what extent the standardized concept of need-based care on Behavioural and Psychological Symptoms of Dementia (BPSD), and formal caregiver distress, is superior when compared to spending more time or standard care with residents with BPSD. METHODS: A longitudinal cluster randomized controlled study in 23 nursing homes in Belgium with 3 parallel groups was set up. A total of 481 residents with dementia participated. Formal ...

The role of maladaptive personality in behavioural and psychological symptoms in dementia Vrije Universiteit Brussel

Kato Dero, Sebastiaan van Alphen, Esther Hoogenhout, Gina Rossi

BACKGROUND: Although research demonstrated a significant link between premorbid normative personality traits and the severity of behavioural and psychological symptoms in dementia (BPSD) and associated emotional distress of the caregiver, little is known about the relationship of BPSD symptoms and associated distress with maladaptive traits.

METHOD: Informants (N = 182) of Dutch nursing home residents with dementia aged 65+, completed ...

Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia Universiteit Gent

Ellen Van Leeuwen, Mirko Petrovic, Marie van Driel, An De Sutter, Tom Declercq, Thierry Christiaens
Background : Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. ...

Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in elderly patients with dementia Universiteit Gent

Tom Declercq, Mirko Petrovic, Majda Azermai, An De Sutter, Marie van Driel, Thierry Christiaens
Background Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in dementia, although the literature is sceptical about their long-termuse for this indication. Their effectiveness is limited and there is concern about adverse effects, including higher mortality with long-term use. When behavioural strategies have failed and drug therapy is instituted, regular attempts to withdraw these drugs are recommended. Physicians, ...

Behavioural and psychological symptoms of dementia in Down syndrome: early indicators of clinical Alzheimer's disease? Universiteit Antwerpen

Alain D. Dekker, Andre Strydom, Antonia M. W. Coppus, Dean Nizetic, Yannick Vermeiren, Petrus J. W. Naude, Debby Van Dam, Marie-Claude Potier, Juan Fortea, Peter De Deyn, et al.
Behavioural and Psychological Symptoms of Dementia (BPSD) are a core symptom of dementia and are associated with suffering, earlier institutionalization and accelerated cognitive decline for patients and increased caregiver burden. Despite the extremely high risk for Down syndrome (DS) individuals to develop dementia due to Alzheimer's disease (AD), BPSD have not been comprehensively assessed in the DS population. Due to the great variety of DS ...

Implication of reward alterations in the expression of negative symptoms in 22q11.2 deletion syndrome: a behavioural and DTI study KU Leuven

Maude Schneider
Alterations of the reward system have been proposed as one of the core mechanisms underlying the expression of negative symptoms in schizophrenia. Specifically, deficits in specific reward components and white matter (WM) integrity of the reward system have been highlighted. The putative link between negative symptoms and the hedonic experience, or structural connectivity of the reward system has never been examined in the 22q11.2 deletion ...