Bayesian Nonlinear Hierarchical Models: Applications in Preclinical Pharmacometrics Universiteit Hasselt
Although Bayesian methods are expanding considerably in various scientific areas, their applications in the field of pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation is still relatively limited. In this work, Bayesian techniques are used to facilitate the estimation of a novel PK/PD model which is developed to quantify the extent of PD synergy between two compounds using historical in vivo data. The model is fitted using package ...