Publicaties
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Ecology and molecular biology of bacterial adaptation to pesticides KU Leuven
Pesticides are indispensable for ensuring a stable food supply chain and their world-wide use is increasing. However, they are a major environmental concern due to their recalcitrant nature and toxicity towards non-target organisms. Despite increasingly stringent regulations, pesticides continue to exceed mandated threshold levels in ground and surface waters. To address this persistence issue, a better understanding of the environmental fate of ...
Topical **Lactobacillus** applications for modulation of the vaginal and skin microbiota Universiteit Antwerpen
Op en in ons lichamen dragen we een grote collectie aan micro-organismen, waar we naar verwijzen als ‘onze microbiota’. Ondanks dat bacteriën en gisten nog vaak een negatieve connotatie hebben en geassocieerd worden met infecties, heeft het merendeel van deze microorganismen een neutraal of zelfs positief effect op onze gezondheid. In verschillende pathologieën is de balans tussen de gunstige en potentieel gevaarlijke microorganismen verstoord. ...
Positioning the preventive potential of microbiome treatments for cystic fibrosis in the context of current therapies Universiteit Antwerpen
Antibiotics and cystic fibrosis transmembrane conductance regulator (CFTR) modulators play a pivotal role in cystic fibrosis (CF) treatment, but both have limitations. Antibiotics are linked to antibiotic resistance and disruption of the airway microbiome, while CFTR modulators are not widely accessible, and structural lung damage and pathogen overgrowth still occur. Complementary strategies that can beneficially modulate the airway microbiome ...
Human inflammatory response of endotoxin affected by particulate matter-bound transition metals Universiteit Antwerpen KU Leuven
Bacterial endotoxins are a component of particulate matter (PM) with anticipated health implications, yet we know little about how host reception of endotoxin through toll-like receptor 4 (TLR4) is affected by its association with other PM components. Subsequently, we investigated the relationship between endotoxin concentration (recombinant Factor C (rFC) assay) and host recognition (HEK Blue-TLR4 NF-kB reporter cell line based assay) in ...
Unravelling the bacterial community composition of Valerianella locusta, a cold tolerant plant Universiteit Gent
Low temperatures greatly affect plant growth. Besides the development of own protection mechanisms, plants may rely on microorganisms to help them cope with cold. As Valerianella locusta (lamb’s lettuce) is a cold-adapted plant, it represents an interesting plant to understand how cold affects the root bacteriome. By means of amplicon sequencing of 16S rRNA genes, we identified the taxa forming the main cold root bacteriome of lamb’s lettuce. ...
Analysis of the food safety and microbial ecology of fermented carrot juice Universiteit Antwerpen
Artisanale voedselfermentaties worden vaak bestempeld als één van de oudste biotechnologieprocessen ter wereld, omdat ze al gebruikt werden door de Egyptenaren om verse voeding langer te bewaren. Daarnaast stijgt hun populariteit ook bij haute cuisine chefs door hun toegevoegde aroma’s en texturen. Gefermenteerd wortelsap is een voorbeeld van zo’n artisanale groentefermentatie. In dit doctoraatsonderzoek werd er onderzoek gedaan naar de ...
Phyllosphere bacterial communities in urban green areas throughout Europe relate to urban intensity Universiteit Antwerpen
We found that phyllosphere bacterial communities in European cities are associated to urban intensity and that this effect is mediated by several combined stress factors. The phyllosphere harbours a diverse and specific bacterial community, which influences plant health and ecosystem functioning. In this study, we investigated the impact of urban green areas connectivity and size on the composition and diversity of phyllosphere bacterial ...
Populieren en hun bacteriën: een sanering hoeft niet altijd duur en ingrijpend te zijn Universiteit Hasselt
De aanplanting van populieren in combinatie met het toevoegen van bacteriën bleek succesvol om een grondwaterverontreiniging op een Vlaamse site aan te pakken. Uitgaande van deze case studie wordt de kosteneffectiviteit van fytoremediatie vergeleken met die van andere, meer conventionele saneringstechnieken.
Exposing the small protein load of bacterial life Universiteit Gent
The ever-growing repertoire of genomic techniques continues to expand our understanding of the true diversity and richness of prokaryotic genomes. Riboproteogenomics laid the foundation for dynamic studies of previously overlooked genomic elements. Most strikingly, bacterial genomes were revealed to harbor robust repertoires of small open reading frames (sORFs) encoding a diverse and broadly expressed range of small proteins, or sORF-encoded ...