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Degradation kinetics of artesunate for the development of an ex-tempore intravenous injection Universiteit Gent

Fanta Gashe Fufa, Evelien Wynendaele, Bart De Spiegeleer, Sultan Suleman
Background Artesunate is recommended by the World Health Organization (WHO) for parenteral treatment of severe Plasmodium falciparum malaria. However, artesunate is inherently unstable in an aqueous solution and hydrolyses rapidly after its preparation for injection. Therefore, the aim of the study was to evaluate the stabilizing effects of phosphate buffer and mannitol against short-term (ex-tempore) artesunate hydrolysis. Methods A HPLC-UV ...

Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium Instituut voor Tropische Geneeskunde

A.R. Kreeftmeijer-Vegter, P.J. van Genderen, L.G. Visser, W.F. Bierman, J. Clerinx, C.K. van Veldhuizen, P.J. de Vries
BACKGROUND: Intravenous (IV) artesunate is the treatment of choice for severe malaria. In Europe, however, no GMP-manufactured product is available and treatment data in European travellers are scarce. Fortunately, artesunate became available in the Netherlands and Belgium through a named patient programme. This is the largest case series of artesunate treated patients with severe malaria in Europe. METHODS: Hospitalized patients treated with IV ...

Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso Instituut voor Tropische Geneeskunde Universiteit Antwerpen

I. Valea, H. Tinto, M Coulibaly, L.C. Toe, N. Lindegardh, J. Tarning, J.P. Van geertruyden, D'Alessandro, G.R. Davies, S.A. Ward, et al.
OBJECTIVES: Mefloquine/artesunate has recently been developed as a fixed-dose combination, providing a promising rescue/alternative treatment for malaria during pregnancy. However, limited data are available on the effect of pregnancy on its pharmacokinetic properties. This study was conducted to assess the pharmacokinetic properties of mefloquine/carboxymefloquine and artesunate/dihydroartemisinin in pregnant and non-pregnant women with ...

Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria Instituut voor Tropische Geneeskunde

C. Van Malderen, Jean-Pierre Van Geertruyden, S. Machevo, R González, Q. Bassat, A Talisuna, A Yeka, C Nabasumba, P. Piola, A. Daniel, et al.
BACKGROUND: Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely stopped because of safety concerns secondary to its associated risk of haemolytic ...