Publicaties
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Performance characteristics of rheumatoid factor and anti-cyclic citrullinated peptide antibody assays may impact ACR/EULAR classification of rheumatoid arthritis KU Leuven
Rheumatoid factor (RF) and anti-cyclic citrullinated protein/peptide antibodies (ACPA) are integrated in the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for rheumatoid arthritis (RA). The objectives of this study were to evaluate the technical and diagnostic performance of different RF and ACPA assays and to evaluate whether differences in performance impact RA classification.
A recombinant dromedary antibody fragment (VHH or nanobody) directed against human duffy antigen receptor for chemokines Vrije Universiteit Brussel
Fy blood group antigens are carried by the Duffy antigen receptor for chemokines (DARC), a red cells receptor for Plasmodium vivax broadly implicated in human health and diseases. Recombinant VHHs, or nanobodies, the smallest intact antigen binding fragment derivative from the heavy chain-only antibodies present in camelids, were prepared from a dromedary immunized against DARC N-terminal extracellular domain and selected for DARC binding. A ...
Engineering and expression of bibody and tribody constructs in mammalian cells and in the yeast Pichia pastoris Vrije Universiteit Brussel
Bibodies and tribodies are therapeutic antibody derivatives with sizes of approximately 75 and 100 kDa, respectively. This makes them smaller than full-size monoclonal antibodies, leading to better tissue penetration. Compared to the smaller scFv and Fab fragments, the bi- and tribody formats have the additional advantage of a slower renal clearance. However, the cost-effective and efficient production of these and other antibody derivatives is ...
Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: Adjusting the bullet to its target Vrije Universiteit Brussel
Introduction: Molecular imaging is a fast developing field and there is a growing need for specific imaging tracers in the clinic. Camelid single-domain antibody-fragments (sdAbs) recently emerged as a new class of molecular imaging tracers. Areas covered: We review the importance of molecular imaging in the clinic and the use of camelid sdAbs as in vivo molecular imaging tracers. Interest in imaging tracers based on antibody fragments or ...