Decreased levels of active uPA and KLK8 assessed by $\left[^{111}In\right]$MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy Universiteit Antwerpen
Objective: Urokinase-type plasminogen activator (uPA) and kallikrein-related peptidase 8 (KLK8) are serine proteases that contribute to extracellular matrix (ECM) remodeling after brain injury. They can be labelled with the novel radiotracer [In-111]MICA-401. As the first step in exploring the applicability of [In-111]MICA-401 in tracing the mechanisms of postinjury ECM reorganization in vivo, we performed in vitro and ex vivo studies, assessing ...