Amine Activation: N-Arylamino Acid Amide Synthesis from Isothioureas and Amino Acids. IF 5.123 Vrije Universiteit Brussel Universiteit Antwerpen
N-arylamino acid amides have been synthesized via a novel method based on N-arylamine activation into isothioureas followed by reaction with amino acids under iron catalysis. The activated N-arylamines are easily prepared using a three-component reaction with commercial reagents, tert-butylisocyanide and S-phenyl benzenethiosulfonate. The protocol shows a broad functional group compatibility, with respect to side chain functionality of the ...