Publicaties
Pouvoir infectant du sang de rats albinos, après injection sous-cutanée massive de Trypanosoma congolense et de Trypanosoma brucei Instituut voor Tropische Geneeskunde
Sur le rapport du poids de la rate ou du foie au poids du corps, chez des rats blancs (variété albinos de Mus decumanus), non infectés, ainsi que chez les animaux de mème espèce, préalablement infectés de Trypanosoma congolense ou de Trypanosoma brucei, p Instituut voor Tropische Geneeskunde
High resolution mapping of OCA2 intragenic rearrangements and identification of a founder effect associated with a deletion in Polish albino patients Vrije Universiteit Brussel KU Leuven
Oculocutaneous albinism type 2 (OCA2) represents about 30% of OCA worldwide. Using quantitative multiplex fluorescent PCR and very high-resolution array-CGH focussed on the OCA2 gene and surrounding regions in 15q12, we identified new rearrangements. Deletion 1, encompassing exons 3-20, was present in three patients (including one in the homozygous state), and Deletion 2 (exons 1-20) was found in one patient (heterozygous state). The ...
Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infection Instituut voor Tropische Geneeskunde
Spinoza and biblical philology in the Dutch republic, 1660-1710 Universiteit Gent
Targeted mutagenesis using CRISPR-Cas9 in the chelicerate herbivore Tetranychus urticae Universiteit Gent
The use of CRISPR-Cas9 has revolutionized functional genetic work in many organisms, including more and more insect species. However, successful gene editing or genetic transformation has not yet been reported for chelicerates, the second largest group of terrestrial animals. Within this group, some mite and tick species are economically very important for agriculture and human health, and the availability of a gene-editing tool would be a ...
Multigene panel sequencing of established and candidate melanoma susceptibility genes in a large cohort of Dutch non-CDKN2A/CDK4 melanoma families Vrije Universiteit Brussel
Germline mutations in the major melanoma susceptibility gene CDKN2A explain genetic predisposition in only 10-40% of melanoma-prone families. In our study we comprehensively characterized 488 melanoma cases from 451 non-CDKN2A/CDK4 families for mutations in 30 established and candidate melanoma susceptibility genes using a custom-designed targeted gene panel approach. We identified (likely) pathogenic variants in established melanoma ...