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Nodding syndrome and epilepsy in onchocerciasis endemic regions Instituut voor Tropische Geneeskunde Universiteit Antwerpen

Robert Colebunders, J.L. Mokili, J.F. Wamala, J. Kaducu, L. Kur, F. Tepage, M. Mandro, G. Mucinya, G. Mambandu, M.Y. Komba, et al.
BACKGROUND: Nodding syndrome (NS) is an epilepsy disorder occurring in children in South Sudan, northern Uganda and Tanzania. The etiology of NS is unknown, but epidemiological studies demonstrate an association between NS and onchocerciasis. METHODS: Between November 2013 and July 2015 we visited onchocerciasis endemic regions in South Sudan, Uganda, and the Democratic Republic of the Congo (DRC) to assess the epilepsy situation. In South Sudan ...

TLTF in cerebrospinal fluid for detection and staging of T. b. gambiense infection Instituut voor Tropische Geneeskunde

M.H. Abdulla, M. Bakhiet, Veerle Lejon, J. Andersson, J. McKerrow, O. Al-Obeed, R.A. Harris
BACKGROUND: Trypanosome-derived lymphocyte triggering factor (TLTF) is a molecule released by African trypanosomes that interacts with the host immune system, resulting in increased levels of IFN-gamma production. METHODOLOGY/PRINCIPAL FINDINGS: TLTF and anti-TLTF antibodies were assessed in sera and cerebrospinal fluid (CSF) from patients infected with Trypanosoma brucei gambiense (T. b. gambiense) in an attempt to identify alternative markers ...

Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness Instituut voor Tropische Geneeskunde

N. Tiberti, Veerle Lejon, A Hainard, B. Courtioux, X Robin, N. Turck, K. Kristensson, E. Matovu, J.C. Enyaru, D Mumba Ngoyi, et al.
BACKGROUND: Post-therapeutic follow-up is essential to confirm cure and to detect early treatment failures in patients affected by sleeping sickness (HAT). Current methods, based on finding of parasites in blood and cerebrospinal fluid (CSF) and counting of white blood cells (WBC) in CSF, are imperfect. New markers for treatment outcome evaluation are needed. We hypothesized that alternative CSF markers, able to diagnose the meningo-encephalitic ...

Profile of suicide in rural Cameroon: are health systems doing enough? Instituut voor Tropische Geneeskunde

Basile Keugoung, E.T. Kongnyu, J. Meli, Bart Criel
OBJECTIVES: To describe the characteristics of suicide and assess the capacity of health services at the district level in Cameroon to deliver quality mental health care. METHODS: The study covered the period between 1999 and 2008 and was carried out in Guidiguis health district which had a population of 145 700 inhabitants in 2008. Data collection was based on psychological autopsy methods. To collect data, we used documentary review of medical ...

Impact of retreatment with an artemisinin-based combination on malaria incidence and its potential selection of resistant strains: study protocol for a randomized controlled clinical trial Instituut voor Tropische Geneeskunde

H. Muvindo Mahoko, C Nabasumba, Halidou Tinto, D'Alessandro, M.P. Grobusch, Jean-Pierre Van Geertruyden
BACKGROUND: Artemisinin-based combination therapy is currently recommended by the World Health Organization as first-line treatment of uncomplicated malaria. Recommendations were adapted in 2010 regarding rescue treatment in case of treatment failure. Instead of quinine monotherapy, it should be combined with an antibiotic with antimalarial properties; alternatively, another artemisinin-based combination therapy may be used. However, for ...