Publicaties
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The efficacy and safety of zidovudine alone or as cotherapy with acyclovir for the treatment of patients with AIDS and AIDS-related complex; a double-blind, randomized trial Instituut voor Tropische Geneeskunde
The efficacy and safety of zidovudine with or without acyclovir in the treatment of patients with AIDS-related complex Instituut voor Tropische Geneeskunde
Topical use of 5% acyclovir cream for the treatment of occult and verrucous equine sarcoids : a double-blinded placebo-controlled study Universiteit Gent
Topical distribution of acyclovir in normal equine skin and equine sarcoids : an in vitro study Universiteit Gent
Pharmacokinetics and clinical efficacy of acyclovir in the treatment of equine herpes virus type 1 infections Universiteit Gent
Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives KU Leuven
Herpes simplex viruses (HSV), the causative agents of recurrent orofacial and anogenital infections, can cause significant morbidity and mortality in both immunocompetent and immunocompromised individuals. In immunocompromised patients, HSV tends to be more persistent with chance of dissemination. The nucleoside analogue acyclovir has drastically improved the management of HSV infections although acyclovir resistant strains have been reported in ...
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2 KU Leuven
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 2 (HSV-2) are responsible for 2 intersecting epidemics in which the disease caused by 1 virus facilitates the transmission of and pathogenesis by the other. Therefore, suppression of one virus infection will affect the other. Acyclovir, a common antiherpetic drug, was shown to directly suppress both viruses in coinfected tissues. However, both antiviral ...
The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir KU Leuven
Chitosan is object of pharmaceutical research as a candidate permeability enhancer. However, chitosan was recently shown to reduce the oral bioavailability of acyclovir in humans. The effect of chitosan on two processes determining the oral bioavailability of acyclovir, bioaccessibility and intestinal absorption, was now investigated. Acyclovir's bioaccessibility was studied using the dynamic TNO gastro-Intestinal Model (TIM-1). Four epithelial ...