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Rethinking Food Anticipatory Activity in the Activity-Based Anorexia Rat Model KU Leuven
When a rat is on a limited fixed-time food schedule with full access to a running wheel (activity-based anorexia model, ABA), its activity level will increase hours prior to the feeding period. This activity, called food-anticipatory activity (FAA), is a hypothesized parallel to the hyperactivity symptom in human anorexia nervosa. To investigate in depth the characteristics of FAA, we retrospectively analyzed the level of FAA and activities ...
Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases KU Leuven Universiteit Antwerpen
Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The present study describes the synthesis and biochemical characterization of novel activity-based probes targeting trypsin-like serine proteases. We developed an extensive library of activity-based probes with "clickable" affinity tags and a diaryl ...
Synthesis of Novel Fluorescent Phosphonate and Phosphinate Activity-based Probes and their Application for the Detection of Serine Proteases KU Leuven
For its immune system to function properly, the human body relies on a multitude of signaling processes executed by many different types cells. The most common one of these cell types is the neutrophil. Neutrophil cells patrol the blood and once encountering pathogens, they react to kill it making use of their armory contained in different types of granules. The neutrophil serine proteases are an important part of this armory and they can, for ...
Calibrating Activity-based Models With External OD Information: An Overview Of Different Possibilities Universiteit Hasselt
Many practitioners question the advantages of activity-based models over conventional four-step models in terms of replication of traffic counts. Therefore, in this paper, a framework is highlighted that actively links travel demand models in general, and activity-based models in particular, with traffic counts. Two approaches are presented that calibrate activity-based models with traffic counts, namely an indirect and a direct approach. The ...
An examination of the accuracy of an activity-based travel simulation against smartcard and navigation device data Universiteit Hasselt
Activity-based travel simulators have been experiencing difficulty obtaining high quality activity-travel data and network information, which limits the applicability of the simulator to real world problems. For example, accurate information regarding travel time, link traffic volume and trip distribution is essential for sensitivity analysis using an activity-based travel simulator. Survey data, which relies on respondents' memories, is ...
Calibrating Activity-Based Models with External Origin-Destination Information Overview of Possibilities Universiteit Hasselt
Many practitioners question the advantages of activity-based models over conventional four-step models in regard to replication of traffic counts. This paper highlights a framework that actively links travel demand models in general and activity-based models in particular with traffic counts. Two approaches are presented that calibrate activity-based models with traffic count-an indirect and a direct approach. The indirect approach tries to ...
Machine learning to assist in large-scale, activity-based synthetic cannabinoid receptor agonist screening of serum samples Universiteit Gent
Background Synthetic cannabinoid receptor agonists (SCRAs) are amongst the largest groups of new psychoactive substances (NPS). Their often high activity at the CB1 cannabinoid receptor frequently results in intoxication, imposing serious health risks. Hence, continuous monitoring of these compounds is important, but challenged by the rapid emergence of novel analogues that are missed by traditional targeted detection strategies. We addressed ...
Investigation of the Required Travel Survey Size for Training an Activity-Based Traffic Demand Model for Flanders Implemented in the FEATHERS Simulation Platform Universiteit Hasselt
It has been known from many years now that operational activity-based models need a lot of survey data to incorporate behavioural decision making of people. While there have been contributions from the field of statistics about how much survey data is needed to come to reliable estimates of behaviour; an obvious question which is often overlooked in the domain is how much survey data is really necessary to obtain an activity-based model that is ...
Implementation Framework and Development Trajectory of FEATHERS Activity-Based Simulation Platform Universiteit Hasselt
In order to facilitate the development of dynamic activity-based models for transport demand, the FEATHERS framework was developed. This framework suggests a four stage development trajectory for a smooth transition from the four-step models towards static activity based models in the short term and dynamic activity based models in the longer term. The development stages discussed in this paper range from an initial static activity-based model ...