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Eculizumab improves fatigue in refractory generalized myasthenia gravis Universiteit Gent

Henning Andersen, Renato Mantegazza, Jing Jing Wang, Fanny O'Brien, Kaushik Patra, James F, Jr Howard, the REGAIN Study Group, Jan De Bleecker
Purpose: To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using the Quality of Life in Neurological Disorders (Neuro-QOL) Fatigue subscale, and to evaluate correlations between improvements in Neuro-QOL Fatigue and other clinical endpoints. Methods: Neuro-QOL Fatigue, MG Activities of Daily Living (MG-ADL), Quantitative MG ...

Ghent developmental balance test, manual Universiteit Gent

Alexandra De Kegel, Hilde Van Waelvelde
Balance is a fundamental component of movement, involving the ability to recover from instability and to avoid instability, to anticipate balance disturbances. Various developmental motor disorders cause poor balance, resulting in difficulties with postural control and disturbing the development of numerous activities of daily living. To plan interventions for these young children with motor disabilities, a specific measure to evaluate balance ...

Daily Living Activities Recognition and Segmentation in Older Adults with Sensor Technology and Machine Learning Algorithms KU Leuven

Yiyuan Zhang
In Europe as well as in China the fraction of older persons continues to rise compared to the fraction of the active population. This growing group of older people requires an individualised and adaptive care plan as their health declines. The level of self-reliance is one of the strongest contributing factors in the care plan. Due to the development of wearable sensors and internet-of-things (IOT) sensors, it becomes possible to continuously ...

Self-management interventions for facilitating life participation for persons with kidney failure : a systematic review Universiteit Gent Vrije Universiteit Brussel KU Leuven

Timothy Moreels, Dominique Van de Velde, Justine Goethals, Karsten Vanden Wyngaert, Stijn De Baets, Evi Nagler, Patricia De Vriendt, Wim Van Biesen
Background: For persons with kidney failure life participation is a critically important outcome, strongly linked to quality of life and mortality. To support patients' self-management abilities, three domains are typically emphasized: medical-management, emotional-management and management of everyday life (i.e. role-management). While role-management is strongly linked to life participation, there is currently limited research on interventions ...

Patient perspectives on employment participation in the “hypermobile Ehlers–Danlos syndrome” Vrije Universiteit Brussel Universiteit Gent

Stijn De Baets, Patrick Calders, Liesbeth Verhoost, Marieke Coussens, Inge Dewandele, Fransiska Malfait, Guy Vanderstraeten, Geert Van Hove, Dominique Van de Velde

Background: “Ehlers–Danlos syndrome” (EDS) is a heritable connective disorder influencing multiple aspects of daily life. Most studies have focused on describing the physical symptoms and level of disability, but little knowledge exists about the psychosocial effects of the pathology. Participation in employment is an aspect that strongly influences quality of life of patients with chronic pathologies. This study, therefore, aimed to explore ...

Learning based Quality Indicator Aiding Heart Rate Estimation in Wrist-Worn PPG KU Leuven

Erika Lutin, Chris Van Hoof
Technological advancements and miniaturization of wearable sensors have enabled long-term pervasive physiological monitoring. Wrist-worn photoplethysmography (PPG) sensors, although quite popular owing to their form factor, suffer from poor signal quality in ambulatory settings due to motion artifacts. This affects the reliable estimation of vital cardiac parameters, especially during motion/activities of daily living. Hence, in this paper, we ...

Patient-reported outcome measures for life participation in kidney transplantation: A systematic review KU Leuven

Fabienne Dobbels
For many patients with end-stage kidney disease, transplantation improves survival and quality of life compared with dialysis. However, complications and side effects in kidney transplant recipients can limit their ability to participate in activities of daily living including work, study, and recreational activities. The aim of this study was to identify the characteristics, content, and psychometric properties of the outcome measures used to ...

Task-Specific Perceived Harmfulness Predicts Protective Movement Behaviour in Chronic Low Back Pain Universiteit Hasselt Universiteit Gent KU Leuven

Thomas MATHEVE, Annick TIMMERMANS, Lieven Danneels, Liesbet De Baets
Background/Objectives: There is emerging evidence that task-specific pain-related psychological measures may better predict movement behaviour in chronic low back pain (CLBP) than general pain-related psychological measures. Currently, little is known regarding the prediction of movement duration and movement velocity. Methods: Baseline data from a previously published randomized controlled trial were used (clinicaltrials.gov NCT02773160). ...

Response to cardiac resynchronization therapy in elderly patients (≥70 years) and octogenarians Vrije Universiteit Brussel Universiteit Hasselt

Frederik H Verbrugge, Matthias Dupont, Philippe De Vusser, Maximo Rivero-Ayerza, Hugo Van Herendael, Jan Vercammen, Linda Jacobs, Pieter M Vandervoort, W H Wilson Tang

AIMS: Cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling, improved functional capacity, and better clinical outcome in patients with advanced chronic heart failure, reduced ejection fraction, and evidence of ventricular conduction delay, who are under optimal medical therapy. This study investigated whether these benefits can be extrapolated to older patients, typically not included in randomized clinical ...

Frailty screening in older patients undergoing elective colorectal surgery: Comparative study of seven screening instruments KU Leuven

Katleen Fagard, Mieke Deschodt
BACKGROUND: Frailty screening instruments are increasingly studied as risk predictors for adverse postoperative outcomes. However, because of the lack of comparative research, it is unclear which screening instrument performs best. This study therefore compared the diagnostic accuracy of seven frailty screening instruments for adverse postoperative outcomes in patients aged ≥70 years undergoing colorectal surgery. METHODS: We conducted a ...