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Macrofaagsterfte als farmacologisch doelwit bij atherosclerose Universiteit Antwerpen
Atherosclerose is een chronische inflammatoire aandoening die gekenmerkt wordt door de geleidelijke opbouw van plaques in de vaatwand van middelgrote en grote slagaders. De laatste decennia is de behandeling van atherosclerose vooral gericht op het verlagen van de lipidenspiegel. Sommige patiënten reageren echter onvoldoende op lipidenverlagende therapie en hebben daarom nog steeds een resterend cardiovasculair risico. Deze problematiek ...
Inhibitie van apoptose, autofagie en necrose in atherosclerose: potentiële strategieën voor plaquestabilisatie? Universiteit Antwerpen
Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis Universiteit Antwerpen
Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stable and a vulnerable, rupture-prone lesion. The need for plaque-stabilizing therapies is high, and for a long time the lack of a ...
Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis Universiteit Gent
Background : Previous studies implicated Toll-like receptor signaling as a critical pathogenic pathway in atherosclerosis, but the cell-specific mechanisms by which Toll-like receptors act to control atherosclerotic plaque development remain poorly understood.Methods and Results : To study the cell-specific role of tumor necrosis factor receptor-associated factor 6 (TRAF6) in atherosclerosis, we generated ApoE(-/-) mice with endothelial cell-or ...
Circulating oxidized low-density lipoprotein : a biomarker of atherosclerosis and cardiovascular risk? Universiteit Gent
Low-density lipoproteins (LDLs) are susceptible to structural modifications by oxidation, particularly the small dense LDL particles. The formation of lipid peroxidation derivates, such as thiobarbituric reactive substances, conjugated dienes, lipid hydroperoxides, and aldehydes, is associated with changes in apolipoprotein conformation and affects the functional properties of LDLs. Oxidized LDL (oxLDL) formation in the subendothelial space of ...
Linking $CD11b^{+}$ dendritic cells and natural killer T cells to plaque inflammation in atherosclerosis Universiteit Antwerpen
Atherosclerosis remains the leading cause of death and disability in our Western society. To investigate whether the dynamics of leukocyte (sub)populations could be predictive for plaque inflammation during atherosclerosis, we analyzed innate and adaptive immune cell distributions in blood, plaques, and lymphoid tissue reservoirs in apolipoprotein E-deficient (ApoE−/−) mice and in blood and plaques from patients undergoing endarterectomy. ...
Programmed death of macrophages in atherosclerosis Universiteit Antwerpen
Atherosclerosis is a progressive inflammatory disorder of the arterial vessel wall characterized by substantial infiltration of macrophages, which exert both favourable and detrimental functions. Early in atherogenesis, macrophages can clear cytotoxic lipoproteins and dead cells, preventing cytotoxicity. Efferocytosis - the efficient clearance of dead cells by macrophages - is crucial for preventing secondary necrosis and stimulating the release ...
Acetylsalicylic acid reduces passive aortic wall stiffness and cardiovascular remodelling in a mouse model of advanced atherosclerosis Universiteit Antwerpen
Acetylsalicylic acid (ASA) is widely used in secondary prevention of cardiovascular (CV) disease, mainly because of its antithrombotic effects. Here, we investigated whether ASA can prevent the progression of vessel wall remodelling, atherosclerosis, and CV complications in apolipoprotein E deficient (ApoE−/−) mice, a model of stable atherosclerosis, and in ApoE−/− mice with a mutation in the fibrillin-1 gene (Fbn1C1039G+/−), which is a model of ...
Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (Progression of Early Subclinical Atherosclerosis) study Instituut voor Tropische Geneeskunde
Background: Data are limited on the presence, distribution, and extent of subclinical atherosclerosis in middle-aged populations.
Methods and Results: The PESA (Progression of Early Subclinical Atherosclerosis) study prospectively enrolled 4184 asymptomatic participants 40 to 54 years of age (mean age, 45.8 years; 63% male) to evaluate the systemic extent of atherosclerosis in the carotid, abdominal aortic, and iliofemoral territories ...