Publicaties
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Development and validation of non-invasive diagnostic tools for the assessment of arterial stiffness and wave reflections with application in Sub-Saharan Africa Universiteit Gent
Raised uterine artery impedance is associated with increased maternal arterial stiffness in the late second trimester KU Leuven
OBJECTIVE: To assess the relationship between uterine artery Doppler pulsatility index (PI) and maternal global arterial stiffness and aortic stiffness in women at high a priori risk of preeclampsia in the late second trimester of pregnancy. METHODS: A prospective cohort study was performed. 99 women were recruited from the high-risk obstetric ultrasound clinic in the second trimester; median (±IQR) age and gestation were 33 (29-37) years and ...
Isolated nocturnal hypertension and arterial stiffness in a Chinese population KU Leuven
OBJECTIVE: We reported previously that normotensive Chinese had higher nighttime diastolic blood pressure (BP) compared with non-Chinese. We, therefore, studied the prevalence and characteristics of isolated nocturnal hypertension and its association with arterial stiffness, an intermediate sign of target organ damage. METHODS: We recorded ambulatory BP, the central and peripheral systolic augmentation indexes, the ambulatory arterial stiffness ...
Blood pressure variability and arterial stiffness parameters derived from ambulatory blood pressure monitoring KU Leuven
Multiple blood pressure (BP) measurements allow an evaluation of BP variability and BP‑derived arterial stiffness indices. Periodic variations in BP are well known, from beat‑to‑beat BP readings in intra‑arterial measurement to seasonal variations in BP. Diurnal BP variation has been investigated in relation to its prognostic value. People with night‑to‑day BP ratio of 1 or higher, that is, those with a higher nocturnal than daytime BP, were ...
Applanation tonometry in mice a novel noninvasive technique to assess pulse wave velocity and arterial stiffness Universiteit Antwerpen
Arterial stiffening is the root cause of a range of cardiovascular complications, including myocardial infarction, left ventricular hypertrophy, stroke, renal failure, dementia, and death, and a hallmark of the aging process. The most important in vivo parameter of arterial stiffness is pulse wave velocity (PWV). Clinically, PWV is determined noninvasively using applanation tonometry. Unlike the clinical value of arterial stiffness and PWV, ...
Blood flow pattern in the middle cerebral artery in relation to indices of arterial stiffness in the systemic circulation KU Leuven
BackgroundThe brain is perfused at high-volume flow throughout systole and diastole. We explored the association of blood flow in the middle cerebral artery (MCA) with the pulsatile components of blood pressure in the systemic circulation and indices of arterial stiffness.MethodsWe enrolled 334 untreated subjects (mean age, 50.9 years; 45.4% women) who had been referred for ambulatory blood pressure monitoring to Ruijin Hospital, Shanghai, ...
Antihypertensive treatment decreases arterial stiffness at night but not during the day. Results from the Hypertension in the Very Elderly Trial KU Leuven
The main Hypertension in the Very Elderly Trial (HYVET) demonstrated a very marked reduction in cardiovascular events by treating hypertensive participants 80 years or older with a low dose, sustained release prescription of indapamide (indapamide SR, 1.5 mg) to which was added a low dose of an angiotensin converting enzyme inhibitor in two-thirds of cases (perindopril 2-4 mg). This report from the ambulatory blood pressure sub-study ...
Effect of moderate aerobic exercise training on endothelial function and arterial stiffness in CKD stages 3-4 Universiteit Antwerpen
Background: Evidence of a beneficial effect of exercise training on mediators of vascular disease is accumulating in chronic kidney disease (CKD), but its effect on vascular function in vivo still has to be established. The present study was designed to investigate whether a formal aerobic exercise training program improves peripheral endothelial function in patients with CKD stages 3 to 4. Study Design: Randomized controlled trial with a ...
Prognostic Significance of Home Arterial Stiffness Index Derived From Self-Measurement of Blood Pressure: The Ohasama Study KU Leuven
BackgroundArterial stiffness is a stroke risk factor. The home arterial stiffness index (HASI) can be calculated from self-measured blood pressure using the same formula as the calculation of ambulatory arterial stiffness index (AASI).MethodsIn 2,377 inhabitants (baseline age, 35-96 years) without a history of stroke, home blood pressure was measured once every morning for 26 days (median). HASI was defined as 1 minus the regression slope of ...