Prospectieve longitudinale MRI en PET studies en epileptogenese en hersenplasticiteit in epilepsie met behulp van [18F]fluorodeoxyglucose (FDG), [18F]flumazenil (FMZ), en [18F]MK-9470 in kleine proefdieren met epilepsie. KU Leuven
The aim of the project is to investigate epileptogenesis and brain plasticity due to seizures using two complementary animal models that closely represent temporal lobe epilepsy in humans, i.e. the amygdala kindling model and the status epilepticus model. We intend to characterize several neurobiological processes during epileptogenesis and chronic epilepsy in these two animal models using video-EEG monitoring, and in vivo structural (MRI and ...