Publicaties
Factors influencing kidney transplantation rates Vrije Universiteit Brussel
BACKGROUND: Large international differences exist in kidney transplantation (KT) rates. We aimed to investigate which factors may explain the total, deceased donor, and living donor KT rates over the last decade.
METHODS: KT experts from 39 European countries completed the Kidney Transplantation Rate Survey on measures and barriers and their potential effect on the KT rate in their country. In the analyses, countries were divided into ...
Relapse rate in children with nephrotic syndrome during the SARS-CoV-2 pandemic Vrije Universiteit Brussel
BACKGROUND: Viral upper respiratory tract infections trigger nephrotic syndrome relapses. Few data exist on the impact of the SARS-CoV-2 pandemic on the risk of relapse in children with idiopathic nephrotic syndrome (INS).
METHODS: In a Belgian and Italian cohort of children with INS, we performed a retrospective analysis on the number and duration of relapses observed in 3 different periods in 2020: first COVID period, February ...
Risk for excessive anticoagulation during hemodialysis is associated with type of vascular access and bedside coagulation testing Vrije Universiteit Brussel
BACKGROUND: Recommendations and practice patterns for heparin dosing during hemodialysis show substantial heterogeneity and are scantly supported by evidence. This study assessed the variability in unfractionated heparin (UFH) dosing during hemodialysis and its clinical and biological anticoagulatory effects, and identified explanatory factors of heparin dosing.
METHODS: Cross-sectional study assessing UFH dosing, coagulation tests - ...
The clinical frailty scale as a triage tool for ICU admission of dialysis patients with COVID-19 - An ERACODA analysis Vrije Universiteit Brussel
BACKGROUND: Several guidelines recommend using the Clinical Frailty Scale (CFS) for triage of critically ill COVID-19 patients. This study evaluates the impact of CFS on intensive care unit (ICU) admission rate, and hospital- and ICU mortality rates in hospitalized dialysis patients with COVID-19.
METHODS: We analysed data of dialysis patients diagnosed with COVID-19 from the European Renal Association COVID-19 Database. The primary ...
Recovery of dialysis patients with COVID-19 Vrije Universiteit Brussel
BACKGROUND: COVID-19-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients three months after their COVID-19 diagnosis.
METHODS: We analyzed data on dialysis patients diagnosed with COVID-19 from February 1st, 2020-March 31st, 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes ...
Dialyzer Performance During Hemodialysis Without Systemic Anticoagulation Using a Heparin-Grafted Dialyzer Combined With a Citrate-Enriched Dialysate Vrije Universiteit Brussel
RATIONALE AND OBJECTIVE: The EVOCIT study was designed to evaluate dialyzer performance during hemodialysis with and without systemic anticoagulation.
STUDY DESIGN: Randomized, crossover, non-inferiority trial. Noninferiority was defined as a difference of ≤10% for the primary outcome.
SETTING AND PARTICIPANTS: Single hemodialysis center; 26 prevalent patients treated with 617 hemodialysis sessions.
INTERVENTIONS: ...
Sodium-glucose cotransporter 2 inhibitors Vrije Universiteit Brussel
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) reduce albuminuria and hard renal outcomes (decline of renal function, renal replacement therapy and renal death) in patients with/without type 2 diabetes at high cardiovascular or renal risk. The question arises whether baseline albuminuria also influences renal outcomes with SGLT2is as reported with renin-angiotensin-aldosterone system inhibitors. Post hoc analyses focusing on albuminuria ...
Encrusted Uropathy Vrije Universiteit Brussel
Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly Corynebacterium urealyticum. The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The ...
Individualized Isonatremic and Hyponatremic Dialysate Improves Blood Pressure in Patients with Intradialytic Hypertension: A Prospective Cross-Over Study with 24-h Ambulatory Blood Pressure Monitoring Vrije Universiteit Brussel
Background. Intradialytic hypertension, a paradoxical rise in systolic blood pressure from pre- to postdialysis, is a poorly understood and difficult-to-treat phenomenon. We examined the effects of individually adjusted isonatremic and hyponatremic dialysate on intradialytic and interdialytic blood pressure in patients with intradialytic hypertension. Methods. We enrolled 11 patients with intradialytic hypertension in a prospective randomized ...