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Clinical Picture and Treatment of 2212 Patients with Common Variable Immunodeficiency (CVID) KU Leuven
Autoimmune Lymphoproliferative Syndrome is associated with deficiency in anti-polysaccharide antibodies production and a disorganisation of the spleen marginal zone KU Leuven
Autoimmune lymphoproliferative syndrome (ALPS) caused by impaired FAS-mediated apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased risk of invasive bacterial infection, notably following splenectomy. We surveyed a cohort of 100 ALPS patients (including 33 splenectomized) and found that 12 (10 splenectomized) had experienced 23 invasive bacterial infections mainly caused by Streptococcus ...
Mutant ADA2 in Vasculopathies KU Leuven
Clinical picture and treatment of 2212 patients with common variable immunodeficiency KU Leuven
Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders.
Primary ciliary dyskinesia and humoral immunodeficiency - Is there a missing link? KU Leuven
Primary ciliary dyskinesia (PCD) and humoral mmunodeficiency (HID) are both rare disorders which cause recurrent upper and lower respiratory tract infections.
Diagnostic accuracy of nitric oxide measurements to detect primary ciliary dyskinesia KU Leuven
Primary Ciliary Dyskinesia (PCD) is an orphan disease characterized by recurrent respiratory infections and an increased prevalence of situs inversus and male infertility. Low nasal Nitric Oxide (nNO) is used as a new test to diagnose PCD. The test sensitivity is good, but specificity has not been studied widely. Therefore, we evaluated the diagnostic accuracy of low nNO to diagnose PCD in a large cohort, including healthy patients and different ...