The right-handed parallel β-helix topology of Erwinia chrysanthemi pectin methylesterase Is intimately associated with both sequential folding and resistance to high pressure Universiteit Antwerpen
The complex topologies of large multi-domain globular proteins make the study of their folding and assembly particularly demanding. It is often characterized by complex kinetics and undesired side reactions, such as aggregation. The structural simplicity of tandem-repeat proteins, which are characterized by the repetition of a basic structural motif and are stabilized exclusively by sequentially localized contacts, has provided opportunities for ...