Publicaties

n this dissertation we explore the usage of probabilistic machine learning techniques for calibrating 3D measuring devices and applications. More specifically, we focus on Gaussian processes and line geometry. The research focuses on four main topics: galvanometric setup calibration, surface approximation, camera calibration, and the clinical application of mapping visuospatial neglect. We present a semi-data-driven approach to calibrate ...

This study presents a novel methodology for estimating the master curve of the complex modulus of viscoelastic materials using a combination of optical measurement systems and ultrasonic excitation. Traditional techniques for characterizing properties of viscoelastic materials are often time-consuming and encounter limitations that hinder their accuracy at high strain rates. To address this, a method was proposed that leverages two optical ...

In non-destructive inspections today, the size of the sample being examined is often limited to fit within the field of view of the camera being used. When examining larger specimens, multiple image sequences need to be stitched together into one image. Due to uneven illumination, the combined image may have artificial defects. This manuscript provides a solution for performing line-scan measurements from a sample and combining the images to ...

Preclinical studies have shown that radiotherapy treatments benefit from ultra -high dose rate (UHDR) irradiations. These trigger the FLASH-effect, resulting in a strong decrease in normal tissue toxicity with conserved tumor control probability, compared with conventional irradiations. However, the beam parameters to trigger the FLASH-effect and the radiobiological mechanisms behind it remain to be elucidated. A limiting factor in many studies ...

Visuospatial neglect is a disorder characterised by impaired awareness for visual stimuli located in regions of space and frames of reference. It is often associated with stroke. Patients can struggle with all aspects of daily living and community participation. Assessment methods are limited and show several shortcomings, considering they are mainly performed on paper and do not implement the complexity of daily life. Similarly, treatment ...

In recent years, the Fiber Bragg Grating (FBG) sensor technology has been increasingly utilized as an optical measurement system in various engineering applications, particularly for structural health monitoring (SHM) purposes. This trend can be attributed to the inherent benefits of FBG sensors, such as their small size, immunity to electromagnetic interference, resistance to corrosion, and high accuracy and sensitivity. Various factors cause ...

Background This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug, for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal adenocarcinoma (PDAC). Drug repurposing in oncology offers a cost-effective and time-efficient approach to developing new cancer therapies. Our research focuses on evaluating AF's selective cytotoxicity against cancer cells, identifying RNAseq-based biomarkers to predict AF ...

Bayesian optimisation, known for its minimal requirement of design parameter evaluations, is vital for global industrial process optimisation. It typically employs Gaussian processes as surrogate models for specific objectives. Traditional Bayesian optimisation is directly applied to the actual system. However, numerous industrial applications rely on simulation models. Although these models fail to represent the real system fully, they offer ...

Purpose Inadequate perfusion is the most common cause of partial flap loss in tissue transfer for post-mastectomy breast reconstruction. The current state-of-the-art uses computed tomography angiography (CTA) to locate the best perforators. Unfortunately, these techniques are expensive and time-consuming and not performed during surgery. Dynamic infrared thermography (DIRT) can offer a solution for these disadvantages. Methods The research ...

In this study, we investigate the potential of cold atmospheric plasma (CAP) as a non-contact excitation device, comparing its performance with an ultrasound transmitter. Utilizing a scanning Laser Doppler Vibrometer (LDV), we visualize the acoustic wavefront generated by a CAP probe and an ultrasound sensor within a designated 50 mm x 50 mm area in front of each probe. Our focus lies in assessing the applicability of a CAP probe for exciting a ...