Lipoprotein-targeted therapies for lipotoxic heart disease KU Leuven
Overwhelming epidemiological evidence shows that diabetes mellitus is independently associated with heart failure incidence, with the risk being increased by more than twofold in men and by more than fivefold in women. The most prevalent phenotype of heart failure in patients with obesity and diabetes mellitus is heart failure with preserved ejection fraction (HFpEF) (ejection fraction ≥50%)2. Inflammation has been proposed to be the primary ...