Publicaties
Geen titel beschikbaar Universiteit Gent
Geen titel beschikbaar Universiteit Gent
In vitro gametogenesis and reproductive cloning : can we allow one while banning the other? Universiteit Gent
In vitro gametogenesis (IVG) is believed to be the next big breakthrough in reproductive medicine. The prima facie acceptance of this possible future technology is notable when compared to the general prohibition on human reproductive cloning. After all, if safety is the main reason for not allowing reproductive cloning, one might expect a similar conclusion for the reproductive application of IVG, since both technologies hold considerable and ...
WNT inhibition and increased fibroblast growth factor signaling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation Universiteit Gent
Human embryonic stem cells (hESCs) hold great value for future clinical applications. However, standard culture conditions maintain hESCs in a primed state, which bears heterogeneity in pluripotency and a tendency for spontaneous differentiation. To counter these drawbacks, primed hESCs have been converted to a naive state, but this has restricted the efficiency of existing directed differentiation protocols. In mouse, WNT inhibition by ...
Contemporary pharmacogenetic assays in view of the PharmGKB database Universiteit Gent
Aim: Six modern PGx assays were compared with the Pharmacogenomics Knowledge Base (PharmGKB) to determine the proportion of the currently known PGx genotypes that are assessed by these assays.Materials & methods: Investigated assays were Ion AmpliSeq Pharmacogenomics', iPLEX PGx Pro', DMET Plus,' PharmcoScan,' Living DNA' and 23andMe.'Results: PharmGKB contains 3474 clinical annotations of which 75, 70 and 45% can be determined by ...
Genetic databases and the future of donor anonymity Universiteit Gent
Anonymity is a multifaceted term. Anonymity is rarely eternal or absolute. The use of genetic databases increases the risk of identification of previously anonymous donors. Searches through genetic databases jeopardize the privacy of people who did and did not register on them. Three types of searches can be distinguished in the context of gamete donation: offspring looking for their donor, offspring looking for donor siblings and donors looking ...
The attitude of female students towards sperm donation by their partners Universiteit Gent
Purpose: The aim of this study is to assess the attitude of heterosexual female students towards sperm donation by their partners and towards sperm donation in general.Methods: The method is an online anonymous survey of 1525 female students.Results: The majority of the women had a positive attitude towards sperm donation in general, but only 37% would support their partner if he would want to donate. The highest barriers to accepting donation ...