Dynamic Density Estimation in Heterogeneous Cell Populations KU Leuven
Multicellular systems play a key role in bioprocess and biomedical engineering. Cell ensembles encountered in these setups show phenotypic variability like size and biochemical composition. As this variability may result in undesired effects in bioreactors, close monitoring of the cell population heterogeneity is important for maximum production output, and accurate control. However, direct measurements are mostly restricted to a few cellular ...