Publicaties

1 - 4 of 4 resultaten

Zoek term:

The risks of early-life X-ray exposure: A view on brain aging and Alzheimer’s disease pathology KU Leuven

Emma Coninx
Nowadays, hot topic for many research groups is finding treatment options for the complex and progressive neurodegenerative disorder, Alzheimer's disease (AD). Equally important, however, is finding the initial inducers of AD, which remain largely elusive and is often subject to debate. The major risk factor for AD is unarguable ageing, which is proposed to be accelerated by ionizing radiation exposure. Epidemiological and animal studies have ...

Rosiglitazone Protects Endothelial Cells From Irradiation-Induced Mitochondrial Dysfunction KU Leuven

Emma Coninx, Sarah Baatout
BACKGROUND AND PURPOSE: Up to 50-60% of all cancer patients receive radiotherapy as part of their treatment strategy. However, the mechanisms accounting for increased vascular risks after irradiation are not completely understood. Mitochondrial dysfunction has been identified as a potential cause of radiation-induced atherosclerosis. MATERIALS AND METHODS: Assays for apoptosis, cellular metabolism, mitochondrial DNA content, functionality and ...

High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity KU Leuven

Marlies Verschuuren, Peter Verstraelen, Gerardo Garcia-Diaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H Larsen, Rony Nuydens, Winnok H De Vos
Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological and functional measurements, we found that inhibition of dual leucine zipper kinase (DLK) increased neuronal connectivity in primary cortical cultures. This neuroprotective effect was not only observed in ...

Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose KU Leuven

Bjorn Baselet, Niels Belmans, Emma Coninx, Donna Lowe, Ann Janssen, Arlette Michaux, Kevin Tabury, Kenneth Raj, Roel Quintens, Mohammed A Benotmane, et al.
Background and Purpose: Epidemiological data suggests an excess risk of cardiovascular disease (CVD) at low doses (0.05 and 0.1 Gy) of ionizing radiation (IR). Furthermore, the underlying biological and molecular mechanisms of radiation-induced CVD are still unclear. Because damage to the endothelium could be critical in IR-related CVD, this study aimed to identify the effects of radiation on immortalized endothelial cells in the context of ...