Publicaties
Biomechanical aspects of the normal and cancer-associated lymphatic system Universiteit Gent
The presence of lymph node metastasis is a robust adverse prognostic marker in cancer patients. Solid cancers coopt the existing lymphatic system and induce lymphangiogenesis in the process of lymphatic metastatic spread. While the biochemical and molecular mechanisms that orchestrate lymphatic metastasis have been studied in detail, much less is known about the biomechanical properties of the normal and cancer-associated lymphatic system. Over ...
Anatomy and embryology of the lymphatic system of the colon and rectum Universiteit Gent
Anatomical and temporal patterns of lymph node metastasis in colorectal cancer (Chapter 9) Universiteit Gent
The pathophysiology of metastatic spread in colon cancer (CC) is complex, heterogeneous, and incompletely understood. Traditionally, metastatic spread has been interpreted as a stepwise process, involving orderly progression from the primary tumor to nearby lymph nodes (LNs), henceforth to more distant LNs, and ultimately to distant organs such as the liver. If this behavior is real, efforts to maximize lymphadenectomy may result in removal of ...
Experiment-based 3D modelling of lymph uptake and transport. Universiteit Gent
Contemporary management of locally advanced and recurrent rectal cancer : views from the PelvEx Collaborative Universiteit Gent
Pelvic exenteration is a complex operation performed for locally advanced and recurrent pelvic cancers. The goal of surgery is to achieve clear margins, therefore identifying adjacent or involved organs, bone, muscle, nerves and/or vascular structures that may need resection. While these extensive resections are potentially curative, they can be associated with substantial morbidity. Recently, there has been a move to centralize care to ...
Optimization of intraperitoneal aerosolized drug delivery using computational fluid dynamics (CFD) modeling Universiteit Gent
Intraperitoneal (IP) aerosolized anticancer drug delivery was recently introduced in the treatment of patients with peritoneal metastases. However, little is known on the effect of treatment parameters on the spatial distribution of the aerosol droplets in the peritoneal cavity. Here, computational fluid dynamics (CFD) modeling was used in conjunction with experimental validation in order to investigate the effect of droplet size, liquid flow ...
Consensus guidelines for pressurized intraperitoneal aerosol chemotherapy : technical aspects and treatment protocols Universiteit Gent
An international registry of peritoneal carcinomatosis from appendiceal goblet cell carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy Universiteit Gent
Purpose Peritoneal carcinomatosis from appendiceal goblet cell carcinoma (A-GCC) is a rare and aggressive form of appendiceal tumor. Cytoreductive surgery (CRS) and hyperthermic intra peritoneal chemotherapy (HIPEC) was reported as an interesting alternative regarding survival compared to surgery without HIPEC and/or systemic chemotherapy. Our aim was to evaluate the impact of CRS and HIPEC for patients presenting A-GCC through an international ...
Patient-reported outcomes after pelvic exenteration for colorectal cancer : a systematic review Universiteit Gent
Aim Pelvic exenteration (PE) carries high morbidity. Our aim was to analyse the use of patient-reported outcome measures (PROMs) in PE patients. Method Search strategies were protocolized and registered in PROSPERO. PubMed, Embase, Cochrane Library, Google Scholar, Web of Science and ClinicalTrials.gov were searched with the terms 'patient reported outcomes', 'pelvic exenteration' and 'colorectal cancer'. Studies published after 1980 reporting ...