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Effects of stellate ganglion block on analgesia produced by cervical paravertebral block as established by quantitative sensory testing Universiteit Antwerpen Universiteit Hasselt
Objective. To use quantitative sensory testing (QST) to assess whether a stellate ganglion block (SGB) modulates the analgesia induced by cervical paravertebral block (CPVB). Design. A prospective double-blind randomized controlled trial. Setting. Department of Anesthesia, Antwerp University Hospital, October 2011 to December 2015. Subjects. Twenty-eight adults scheduled for arthroscopy of a nonfractured shoulder were enrolled. Methods. ...
Low back pain Universiteit Antwerpen
Preliminary evaluation of a web-based psychological screening tool in adolescents undergoing minimally invasive pectus surgery Universiteit Antwerpen
Background: Preoperative anxiety and depression are predominant risk factors for increased postoperative pain. Thoracic wall deformities in adolescents often cause low self-esteem, which contributes to psychological concerns. Several studies have suggested a relationship between preoperative mental health support and enhanced recovery after surgery. Objective: This study investigated the validity of screening questionnaires concerning ...
Orofacial neuropathic pain reduces spontaneous burrowing behavior in rats Universiteit Antwerpen
It was recently reported that spontaneous burrowing behavior is decreased after tibial nerve transection, spinal nerve transection and partial sciatic nerve ligation. It was proposed that spontaneous burrowing could be used as a measure of the impact of neuropathic pain after peripheral nerve injury. It has remained unclear whether the reduction in burrowing behavior is caused directly by pain or hypersensitivity in the affected limbs, making it ...
Implementation of an enhanced recovery pathway for minimally invasive pectus surgery Universiteit Antwerpen
Background: Pectus excavatum and pectus carinatum are the most common chest wall deformities. Although minimally invasive correction (minimally invasive repair of pectus, MIRP) has become common practice, it remains associated with severe postoperative pain. Preoperative psychosocial factors such as anxiety and low self-esteem can increase postsurgical pain. Early detection of psychological symptoms, effective biopsychosocial perioperative ...
Differential drug effects on spontaneous and evoked pain behavior in a model of trigeminal neuropathic pain Universiteit Antwerpen
Purpose: Baclofen and morphine have shown efficacy against mechanical allodynia after infraorbital nerve chronic constriction injury (IoN-CCI). No drug effects have yet been reported on spontaneous trigeminal neuropathic pain. It has been proposed that the directed face grooming behavior that also develops following IoN-CCI offers a measure of spontaneous trigeminal neuropathic pain. Subjects and methods: We examined the effects of a continuous ...
Functional respiratory imaging after neostigmine- or sugammadex-enhanced recovery from neuromuscular blockade in the anesthetised rat: a randomised controlled pilot study Universiteit Antwerpen
Objectives: Reductions in diaphragm activity are associated with the postoperative development of atelectasis. Neostigmine reversal is also associated with increased atelectasis. We assessed the effects of neostigmine, sugammadex, and spontaneous reversal on regional lung ventilation and airway flow. Methods: Six Sprague-Dawley rats were paralysed with rocuronium and mechanically ventilated until recovery of the train-of-four ratio to 0.5. We ...
The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats Universiteit Antwerpen
E-52862 is a selective sigma R-1 antagonist currently undergoing phase II clinical trials for neuropathic pain and represents a potential first-in-class analgesic. Here, we investigated the effect of single and repeated administration of E-52862 on different pain-related behaviours in several neuropathic pain models in rats: mechanical allodynia in cephalic (trigeminal) neuropathic pain following chronic constriction injury of the infraorbital ...
Impact of topical 5% lidocaine-medicated plasters on sleep and quality of life in patients with postherpetic neuralgia Universiteit Antwerpen
Aim: To determine the impact of 5% lidocaine-medicated plasters on sleep, quality of life and pain in 265 patients with postherpetic neuralgia (PHN). Patients & methods: An 8-week, open-label arm of a double-blind controlled withdrawal study. Results: Patients treated with 5% lidocaine had less trouble falling asleep, used less sleep medication, had fewer awakenings due to pain at night or in the morning and their perception of quality of ...