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Genome-wide SNP analysis reveals no gain in power for association studies of common variants in the Finnish Saami Universiteit Gent Universiteit Antwerpen
The Saami from Fennoscandia are believed to represent an ancient, genetically isolated population with no evidence of population expansion. Theoretical work has indicated that under this demographic scenario, extensive linkage disequilibrium (LD) is generated by genetic drift. Therefore, it has been suggested that the Saami would be particularly suited for genetic association studies, offering a substantial power advantage and allowing more ...