Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity Universiteit Hasselt
Oncostatin M (OSM) is an IL-6 family member which exerts neuroprotective and remyelination-promoting effects after damage to the central nervous system (CNS). However, the role of OSM in neuro-inflammation is poorly understood. Here, we investigated OSM's role in pathological events important for the neuro-inflammatory disorder multiple sclerosis (MS). We show that OSM receptor (OSMR beta) expression is increased on circulating lymphocytes of MS ...