Publicaties
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Interpreting the history of evolutionary biology through a Kuhnian prism : sense or nonsense? Universiteit Gent
What’s wrong with the modern evolutionary synthesis? A critical reply to Welch (2017) Universiteit Gent
Welch (Biol Philos 32(2):263–279, 2017) has recently proposed two possible explanations for why the field of evolutionary biology is plagued by a steady stream of claims that it needs urgent reform. It is either seriously deficient and incapable of incorporating ideas that are new, relevant and plausible or it is not seriously deficient at all but is prone to attracting discontent and to the championing of ideas that are not very relevant, ...
The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution Universiteit Gent
Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes, the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal' interactions among genes sitting in the different individual organisms that constitute a population. It 'black-boxes' the complex 'intra-organismic' molecular and developmental epigenetics mediating between genotypes and phenotypes. To conceptually integrate ...
The origins and physical roots of life’s dual – metabolic and genetic – nature Universiteit Gent
This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein-based life over the RNA world to the earliest, pre-RNA stages of life’s origin, with special emphasis on the metabolism-first versus gene/replicator-first controversy. Secondly, I critically ...
Life's dual nature: a way out of the impasse of the gene-centred 'versus' complex systems controversy on life Universiteit Gent
Living cells and organisms are complex physical systems. Does their organization or complexity primarily rely on the intra-molecular crystalline structure of genetic nucleic acid sequences? Or is it, as critics of the U+2018gene-centredU+2019 perspective claim, predominantly a result of the inter- and supra-molecular U+2013 thus U+2018holisticU+2019 U+2013 network dynamics of genetic and various extra-genetic factors? The twentieth-century ...