Publicaties
Biomanufacturing of protective antibodies and other therapeutics in edible plant tissues for oral applications Universiteit Gent
Recombinant IgA production for mucosal passive immunization, advancing beyond the hurdles Universiteit Gent
The case for plant-made veterinary immunotherapeutics Universiteit Gent
Tobacco seeds as efficient production platform for a biologically active anti-HBsAg monoclonal antibody Universiteit Gent
Plant expression systems for early stage discovery and development of lead therapeutic antibodies Universiteit Gent
BACKGROUND: Antibodies for human clinical applications are predominantly produced in mammalian expression systems, with Chinese hamster ovary (CHO) cells being the gold standard. CHO cells are ideal for the manufacturing of the IgG class of antibodies, but not for the production of complex antibodies like secretory IgAs (SIgAs) and IgMs, which remain unavailable for clinical use. In contrast, plant seeds and leaves hold the promise to produce ...