Revisiting tubercidin against kinetoplastid parasites : aromatic substitutions at position 7 improve activity and reduce toxicity Universiteit Gent Universiteit Antwerpen
Zwitterionic-hydrophilic interaction liquid chromatography for L-ascorbic acid 2-phosphate magnesium, a raw material in cell therapy Universiteit Gent
RORU+03B3t inhibition selectively targets IL-17 producing iNKT and U+03B3U+03B4-T cells enriched in Spondyloarthritis patients Universiteit Gent
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and gamma delta-T cells, but their contribution to SpA is still unclear. Here we describe the presence of particular ROR gamma t(+)T-be(lo)PLZF(-) iNKT and gamma ...
Bacterial quorum sensing peptides as mediators of the gut-brain axis Universiteit Gent
Phosphonodiamidate prodrugs of N-alkoxy analogs of a fosmidomycin surrogate as antimalarial and antitubercular agents Universiteit Gent
Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents Universiteit Gent
Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics Universiteit Gent
Peptides as epigenetic modulators : therapeutic implications Universiteit Gent
Peptides originating from different sources (endogenous, food derived, environmental, and synthetic) are able to influence different aspects of epigenetic regulation. Endogenous short peptides, resulting from proteolytic cleavage of proteins or upon translation of non-annotated out of frame transcripts, can block DNA methylation and hereby regulate gene expression. Peptides entering the body by digestion of food-related proteins can modulate DNA ...
A Surface Acoustic Wave (SAW) biosensor method for functional quantification of E. coli l-asparaginase Universiteit Gent
Biosensors are rising technologies in the pharmaceutical field for medicine discovery, development and Quality Control (QC) stages. Surface acoustic wave (SAW) biosensor employs acoustic waves generated by oscillating a piezoelectric crystal quartz plate to meas. mass and viscosity, and allows to detect and quantify binding events between the analyte and an immobilized interacting ligand. We present here a SAW biosensor based approach for the ...