Drugging the NLRP3 inflammasome : from signalling mechanisms to therapeutic targets Universiteit Gent
Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of the inflammatory response to infection and tissue damage, inflammasomes – and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in particular - have emerged as key regulators in diverse rheumatic, metabolic and neurodegenerative diseases. Similarly to other inflammasome sensors, NLRP3 assembles a ...