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Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model Universiteit Gent
Studies in yeast have shown that a deficiency in Atp12p prevents assembly of the extrinsic domain (F(1)) of complex V and renders cells unable to make ATP through oxidative phosphorylation. De Meirleir et al. (De Meirleir, L., Seneca, S., Lissens, W., De Clercq, I., Eyskens, F., Gerlo, E., Smet, J., and Van Coster, R. (2004) J. Med. Genet. 41, 120-124) have reported that a homozygous missense mutation in the gene for human Atp12p (HuAtp12p), ...
Human metallothionein expression under normal and pathological conditions : mechanisms of gene regulation based on in silico promoter analysis Universiteit Gent
Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus Universiteit Gent Universiteit Antwerpen
The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators Universiteit Gent
De ziekte van Crohn en colitis ulcerosa zijn de belangrijkste chronische ontstekingsziekten van de darm. Recente studies benadrukken het belang van schade aan de epitheelbarrière en defecten in het aangeboren immuunsysteem in het ontstaan van beide ziekten. Deze schade zorgt ervoor dat de interactie tussen de microbiële darmflora en de gastheer niet meer optimaal verloopt. Het darmepitheel dient een fysische barrière te vormen tussen het lumen ...
Reduced metallothionein expression in colonic Crohn's disease: evidence for a new disease-modifying gene Universiteit Gent
Reduced metallothionein expression in colonic Crohn's disease: evidence for it new disease-modifying gene Universiteit Gent
Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts Universiteit Gent
Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic functions of airway structural cells. Methods. Fibroblasts were isolated from nasal inferior turbinate tissue and cultured in the presence of different concentrations of SEB. Preincubation with ...