Persistence of piperacillin concentrations after treatment discontinuation : in cauda venenum? Universiteit Gent
Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients : a prospective observational study Universiteit Gent
Measuring unbound versus total piperacillin concentrations in plasma of critically ill patients : methodological issues and relevance Universiteit Gent
Background: Piperacillin is considered a moderately protein-bound antibiotic (20%-40%), with albumin being an important binding protein. Although infrequently used in practice, different methods to measure the fraction unbound (fu) are available, but uncertainty remains as to what the most appropriate method is. The main goal of this study was to estimate the impact of the methodology used to measure unbound piperacillin in plasma on the fu of ...
ZEB2 in T-cells and T-ALL Universiteit Gent
Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem : a comparison of eight pharmacokinetic models Universiteit Gent
Background: Several population pharmacokinetic (PopPK) models for meropenem dosing in ICU patients are available. It is not known to what extent these models can predict meropenem concentrations in an independent validation dataset when meropenem is infused continuously, Patients and methods: A PopPK model was developed with concentration-time data collected from routine care of 21 ICU patients (38 samples) receiving continuous infusion ...