Publicaties
A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA Universiteit Gent
The importance of non-canonical DNA structures such as G-quadruplexes (G4) and intercalating-motifs (iMs) in the fine regulation of a variety of cellular processes has been recently demonstrated. As the crucial roles of these structures are being unravelled, it is becoming more and more important to develop tools that allow targeting these structures with the highest possible specificity. While targeting methodologies have been reported for G4s, ...
Acid‐resistant BODIPY amino acids for peptide‐based fluorescence imaging of GPR54 receptors in pancreatic islets Universiteit Gent
Photo-induced crosslinking uncovers an antiparallel strand orientation in heterodimeric (EIAALEK)(3)/(KIAALKE)(3) and (EIAALEK)(3)/(RIAALRE)(3) coiled-coil systems Universiteit Gent
We describe for the first time the co-existence of the parallel and antiparallel conformation of the heterodimeric E3/K3 and E3/R3 coiled-coil systems in solution. The introduction of a furanylated amino acid in the (EIAALEK)(3) sequence allowed, upon photo-induced covalent crosslinking, freezing of the respective coiled-coil complexes present in solution. The occurrence of both parallel and antiparallel conformations in solution was supported ...
Cell surface biotinylation using furan cross-linking chemistry Universiteit Gent
Unlocking the secrets of aptamer-small molecule complexes through NMR spectroscopy Universiteit Gent
Several Alphaherpesviruses interact similarly with the NF-κB pathway and suppress NF-κB-dependent gene expression Universiteit Gent
Alphaherpesvirus infection is associated with attenuation of different aspects of the host innate immune response that is elicited to confine primary infections at the mucosal epithelia. Here, we report that infection of epithelial cells with several alphaherpesviruses of different species, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), feline alphaherpesvirus 1 (FHV-1), and bovine alphaherpesvirus 1 (BoHV-1) results in the ...
Effect of salinity drop on susceptibility to WSSV infection in Litopenaeus vannamei shrimp using a per os challenge model Universiteit Gent
Genotyping and phylogeography of Infectious Bronchitis Virus isolates from Pakistan show unique linkage to GI-24 lineage Universiteit Gent
Infectious bronchitis virus (IBV) is prevalent in Pakistan causing enormous economic losses. To date no clear data are available on circulating genotypes and phylogeographic spread of the virus. Hence current study assessed these parameters for all available IBV Pakistani isolates, based on the 9 new sequences, with respect to other Asian and non-Asian countries. Results indicated that all Pakistani isolates belonged to genotype I (GI), with ...