Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1 Universiteit Gent Vlaams Instituut voor Biotechnologie
Background Following solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a challenge due to its narrow therapeutic index and its high inter- and intra-pharmacokinetic (PK) variability. As the contribution of the gut microbiota to drug metabolism is now emerging, it might be explored as one of the factors explaining TAC PK variability. Herein, we explored the consequences of ...